Asked Mar 2, 2019

Which of the following types of mutations will have the most devastating effect on a cell?
A.frameshift mutation
B. missense mutation
C. nonsense mutation
D. silent mutation


Expert Answer

Step 1

Mutations are the permanent changes in the genetic material of an organism. These changes occur in nucleotide sequences and result in alteration of polypeptide sequences translated from that gene. 

Step 2

Thre are two types of gene mutations namely, point mutations and frameshift mutations.

Point mutations are those in which there is swapping of one nucleotide base with other at a single location in gene. This can be replacement of a purine or another purine or pyrimidine and vice versa. As only one base is changed, the affect is limited to maximum one amino acid.

These are further classified as:

1) Missense mutation: In this the mutant codon codes for different amino acid than that coded by normal codon. It brings about the change of one amino acid in polypeptide.

2) Nonsense mutation: In this mutant codon is a stop codon and terminates the process of translation. It results in formation of incomplete polypeptide which is non functional.

3) Silent mutation: In this mutant codon codes for same amino acid as coded by the normal one. It brings about no change in polypeptide chain.

Step 3

Frameshift mutations are those in which one nucleotide is inserted or deleted in the gene. It results in change in reading frame and hence all the codons present after mutation site are changed. 

This changed codon sequence res...

Want to see the full answer?

See Solution

Check out a sample Q&A here.

Want to see this answer and more?

Solutions are written by subject experts who are available 24/7. Questions are typically answered within 1 hour.*

See Solution
*Response times may vary by subject and question.
Tagged in



Related Biology Q&A

Find answers to questions asked by student like you

Show more Q&A add

Q: What components of the nervous system are directly affected by meningitis?

A: The nervous system is the network of neurons and nerve fibers that functions to transmit nerve signa...


Q: Describe the process of development, from fertilization to parturition.

A: Fertilization- It occurs in fallopian tubes and leads to the formation of a diploid zygote.Cleavage-...


Q: if a cat has 38 chromosomes, how many chromosomes are in the following cells? a) hair  b) claw c) sp...

A: Chromosome number usually refers to number of chromosomes present in diploid set i.e 2n. All the som...


Q: What are the bacterial cell targets of the different antibiotics?

A: Antibiotics are antimicrobial substances that control or inhibit the growth of microorganisms, parti...


Q: The carrier molecule in the ETC can bypass the next carrier in the chain and transfer electrons dire...

A: The electron transport chain (ETC) refers to a series of molecular complexes that transfer electrons...


Q: 4. In dogs, the tendency to bark while traliling is due to a dominant gene while silent trailing is ...

A: In dogs, the tendency to bark while trailing is dominant over silent trailing. Let the gene responsi...


Q: Which of the following is NOT a difference in blood between males and females? A.Males have a larger...

A: Blood is a body fluid that transports oxygen (O2) and carries nutrients to all parts of the body. Mo...


Q: How can UV radiation, Gamma radiation, and Filtration of controlling microbial growth affect cells?

A: Several physical methods are used to control the growth of microorganisms. Radiation and filtration ...


Q: Mosquitos are the most common vector for malaria. How do mosquitos acquire the initial plasmodium in...

A: Malaria is caused by the Plasmodium group of parasites. It is characterized by a pattern of alternat...