Which phase are initially inhibited by Sic1.Phosphorylation marks Sic1 for ubiquitinylation by theSCF ubiquitin-protein ligase and proteosomal degradation,releasing activated S phase CDKs that trigger onset of theS phase

TNF-alpha treatment of prostate carcinoma, LNCAP cells decreases cell survival as shown in the graph below. Which of the following would you observe in these cells treated with TNF- alpha? Select all that apply TNF-a 120 100 80 - 60- 40- 20 - 24 72 (hrs) + Control - TNF-a 10ng + TNF-a 100 ng O Activation of extrinsic pathway of apoptosis O Activation of intrinsic pathway of apoptosis Activation of executioner caspases Recruitment of adapter protein FADD to the TNF-alpha receptor LNCAP cell viability (% of control)

Ras activation can activate O MAP kinase O Protein kinase B Phospholipase C O Two of the above O All of the above

When glucose is low and CAMP is present, CAMP's role is to O Activate catabolite activator protein (CAP) Activate RNA Polymerase Activate the repressor Deactivate the repressor

Diagram and describe the four types of regulatory mechanisms of the cyclin-dependent kinases (Cdks)

Same question but two different sections

Using M cyclin-Cdk as a specific model describe the different ways it can be activated or de-activated.

The responses of the cell signalling can be in the nucleus or in the cytoplasm. Describe the mechanisms for these two different responses.

Which of the following is NOT an example of allosteric regulation? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a Phosphorylation of the CTD of RNA polymerase II. b с d Lactose binding to the Repressor protein. GTP binding to elF2. CAMP binding to cAMP protein-dependent kinase

Describe how you would experimentally demonstrate that a specific G beta protein subunit is required for peptide agonist-stimulated increases in MAPK activity.