Why are abnormal Autosome numbers usually lethal?

Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter16: Regulation Of Gene Expression
Section16.4: Genetic And Molecular Regulation Of Development
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Why are abnormal Autosome numbers usually lethal?

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Aneuploidy refers to the presence of abnormal number of chromosomes in a cell due to nondisjunction of chromosomes during cell division. It is characterized by a human cell having 45 or 47 chromosomes instead of the usual 46.

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