Why do cancer cells treated with vitamin E succinate appear to be more vulnerable to rupture of their lysosomal membranes (and subsequent apoptosis) than normal cells? cancer cells often have an alkaline cytosol, which destabilizes the alkaline lysosomes cancer cells often have an alkaline cytosol, which destabilizes the acidic lysosomes cancer cells often have an acidic cytosol, which destabilizes the alkaline lysosomes cancer cells often have an acidic cytosol, which destabilizes the acidic lysosomes all of the above

Why do cancer cells treated with vitamin E succinate appear to be more vulnerable to rupture of their lysosomal membranes (and subsequent apoptosis) than normal cells? cancer cells often have an alkaline cytosol, which destabilizes the alkaline lysosomes cancer cells often have an alkaline cytosol, which destabilizes the acidic lysosomes cancer cells often have an acidic cytosol, which destabilizes the alkaline lysosomes cancer cells often have an acidic cytosol, which destabilizes the acidic lysosomes all of the above

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter2: Cell Physiology

Section: Chapter Questions

Problem 11RE

See similar textbooks

Similar questions

Why do cancer cells treated with vitamin E succinate appear to be more vulnerable to rupture of their lysosomal membranes (and subsequent apoptosis) than normal cells? cancer cells often have an alkaline cytosol, which destabilizes the alkaline lysosomes cancer cells often have an alkaline cytosol, which destabilizes the acidic lysosomes cancer cells often have an acidic cytosol, which destabilizes the alkaline lysosomes D. cancer cells often have an acidic cytosol, which destabilizes the acidic lysosomes all of the above
Why do cancer cells treated with vitamin E succinate appear to be more vulnerable to rupture of their lysosomal membranes (and subsequent apoptosis) than normal cells? A. cancer cells often have an alkaline cytosol, which destabilizes the acidic lysosomes B. cancer cells often have an alkaline cytosol, which destabilizes the alkaline lysosomes C. cancer cells often have an acidic cytosol, which destabilizes the acidic lysosomes D. cancer cells often have an acidic cytosol, which destabilizes the alkaline lysosomes E. all of the above
Cancer cells treated with vitamin E succinate are generally more vulnerable to rupture of their lysosomal membranes (and subsequent apoptosis) than are normal cells, because: cancer cells often have an acidic cytosol, and their lysosomes have an acidic pH too cancer cells often have an acidic cytosol, but their lysosomes have an alkaline pH cancer cells often have an alkaline cytosol, and their lysosomes have an alkaline pH too cancer cells often have an alkaline cytosol, but their lysosomes have an acidic pH all of the above
Many of the cell’s hydrolytic enzymes are located in the lysosome, where the pH is ∼5. What would you expect to be the optimum pH for these enzymes, and why would this protect the rest of the cell from the destructive power of these enzymes upon the accidental rupture of a lysosome?
In addition to vitamin A (retinoic acid), which other fat-soluble vitamin has been shown to make lysosomal membranes more unstable and vulnerable to rupture (when the cytosol is acidic)? vitamin E (in the form of a-tocopheryl succinate) vitamin B12 (in the form of cyanocobalamin) vitamin C (in the form of ascorbic acid) vitamin B2 (in the form of riboflavin) vitamin B1 (in the form of thiamine)
You are investigating a lysosomal storage disease and you discover that newly synthesized lysosome hydrolases (proteins that should be sent to the lysosome) are secreted from the cells rather than being delivered to the lysosomes (where they should normally be located). What is the most likely explanation for this finding? (Hint: what might be different about the proteins that would cause them to not end up in the correct location?)
Which of these amino acids is NOT a common attachment point for sugars in glycoproteins? A) Gly b) Ser c) Thr d) Asn In I-cell disease defective proteins are mislabeled which should be delivered to which organelle? A) nucleus b) mitochondria c) rough endoplasmic reticulum d) lysosome A glycoprotein involved in red blood cell production is: a) hemagglutinin b) erythropoietin c) p-glycoprotein d) cytochrome c
Why does a muscle cell contain many mitochondria and a white blood cell (an immune cell that engulfs bacteria) contain many lysosomes?
Gap junctions between cells allow direct contact of the cytoplasm between neighboring cells. What kind of cells might you find these in and how do they facilitate the function of these cells?
What is the primary characteristic of peripheral membrane proteins? A: They cannot be post-translationally modified. B: They span the entire lipid bilayer, sometimes multiple times. C: Detergents or nonpolar solvents are necessary to remove them from the lipid bilayer. D:Weak intermolecular forces keep them attached to the lipid membrane.
What important ion channel is present in the membrane of a lysosome? What is the function of the ion channel? If enzymes from a lysosome leaked out into the cytosol, what would happen?
Secretory vesicles (destined for exocytosis) that fuse with the plasma membrane continuously, with no requirement for hormones or any other environmental signal, are properly referred to as: the v-SNARES constitutive secretory vesicles (like those that carry lipids, such as phosphatidylcholine) the endosomes regulated secretory vesicles (like those that carry hormones, such as insulin) the t-SNARES