why EGFR play a role in CRC and other cancer?

Q: Explain the mechanism of Warburg effect and how it benefits cancer cells?

A: Warburg effect is a characteristic behavior shown by cancer cells in which their glucose uptake is…

Q: Name four downstream effects of p53 activation.

A: Gene expression is usually accomplished through mRNA transcription and protein synthesis. p53 is a…

Q: Is the presence of oncogenic Ras necessary for transient inflammatory stimulation to induce chronic…

A: Cancer is disease in which there is uncontrolled proliferation of cell.  In organisms, cell…

Q: What is fadh2 used for?

A: FADH2 stands for Flavine adenine dinucleotide. One molecule of FADH2 yield two molecules of ATP.

Q: What enzyme is upregulated in cancer that overcomes cell senescence?

A: Various type of tumor suppressor genes and oncogenes regulate senescence in normal cell.…

Q: Explain the mechanism of Warburg effect and how it benefits cancer cells

A: The question is based on Warburg effect.

Q: What are the normal functions of the BRCA1 tumor suppressor gene?

A: The BRCA1 gene codes for the protein that causes breast cancer type 1. BRCA1 is a human tumour…

Q: Is there a possibility that by manipulating the microenvironment, we could disrupt the signals…

A: Mutator phenotype is seen in cancer cells. This condition is caused by mutations in genes that are…

Q: What significance do BRCA1 and BRCA2 have in regard to developing cancer, and what types of cancer…

A: BRCA 1 & BRCA 2 are found pair in all the organisms where one gene is obtained from each of the…

Q: Explain the Role of proto-oncogenes and tumorsuppressor genes ?

A: The inactivation of tumor suppressor genes induces cancers although the activation of the…

Q: What is happening in all cancer? What process is this disrupting?

A: Cancer in simple term can be referred to a set of diseases which are caused by the production of an…

Q: Identify the two general functions of the proteins encoded bytumor-suppressor genes.

A: Gene is the unit of heredity that is transferred from a parent to offsprings. Proto-oncogenes are…

Q: Mutations that inactivate p53 have a recessive phenotype, whereas mutations affecting Ras are…

A: P53 is a tumor protein, which codes for the protein that regulates the cell cycle and suppresses…

Q: How does constitutively active Ras promote cancer?

A: In physiology carcinogenesis is known as the production of cancerous cells or tumor cells by…

Q: Explain why IC3 is able to stop cancerous cells from dividing ?

A: Tumor-suppressor proteins are those proteins that normally act to stop abnormal cell growth. But…

Q: What are  ras Proto-oncogenes ?

A: Ras Proto-oncogenes - Ras is an example of a proto-oncogene. Here we will know about the Ras…

Q: The myc oncogene increases expression of the glutamine transporter and glutaminase that converts…

A: Cancer is a disease defined by the uncontrolled development of a group of abnormal cells that can…

Q: How can a mutation in a tumor-suppressor gene contribute to the development of cancer?

A: Tumor-suppressor genes are like any other normal genes whose functions include slowing down cell…

Q: What percentage of cells in an organ or a tissue need toexpress a therapeutic gene to alleviate the…

A: Gene therapy is the method that involves the insertion of DNA or sequence of DNA in the cells of the…

Q: Is the CDK present in G2 checkpoint?

A: Various checkpoints control the cell cycle..

Q: How do oncogenes differ from tumor suppressor genes?

A: Oncogenes are a physically and functionally diverse set of genes, the protein products of which act…

Q: How does the multistep model of cancer explain the observation that sporadic cases of retinoblastoma…

A: Disease is a sickness or illness characterized by specific symptoms and signs. Cancer is a…

Q: I understand how nuclear factor-kB (NFKB) works in the inflammatory response but what is the…

A: Nuclear factor-κB (NF-κB), a transcription factor that is essential for inflammatory responses, is…

Q: What are Ras protein and p53? How can mutations in the genes for these proteins contribute to…

A: TP53 is the gene that translates the protein called tumor protein p53 which acts as a tumor…

Q: ''In the cellular regulatory pathways that controlcell growth and proliferation, the products of…

A: Cell regulation involves a complex mechanism of different cell signaling pathways that work in a…

Q: What is fadh2?

A: The coenzymes are organic, non-protein molecules that are necessary for the functioning of the…

Q: Why is the tumor microenvironment important to cancer progression?

A: Cancer progression requires metastasis which in turn is the ability of tumors to migrate within the…

Q: Why do Tbx5 mutations affect limbs and heart but no other tissues?

A: Introduction Mutation can be defined as the change in the DNA sequence or a structural change in the…

Q: How does the epithelial-to-mesenchymal transition (EMT) contribute to tumorigenesis and disease…

A: Epithelial-mesenchymal transition (EMT) could be a method within which epithelial cells acquire…

Q: In your own words, explain each of the hallmarks of cancer. (immortality, produce go signals,…

A: Introduction : Cancer refers to the rapid divisions of abnormal cells in the body and their…

Q: What type of epigenetic changes are associated with cancer?

A: Epigenetic changes or modifications are important for maintenance of tissue specific gene…

Q: How tumor-suppressor mutations contribute to cancer?

A: Cancer - Cancer is a type of disease in which cells divide in an uncontrolled manner. The cells…

Q: What are the major differences between a tumor initiator (e.g., DMBA) and a tumor promoting agent…

A: Cancer is a disease in which cells, almost anywhere in the body, begin to divide uncontrollably…

Q: What is a tumor suppressor? What is an oncogene?

A: Cancer is a diseased condition where the cells show abnormal growth and proliferation. The cancerous…

Q: How might overexpression of proto-oncogenes lead to abnormal cellular proliferation?

A: A proto-oncogene is a cell's normal gene. Proto-oncogenes are plentiful. Each one is in charge of…

Q: what are the normal funtions of the p53 gene

A: p53 gene is also called as tumour suppressor gene or Tp53 gene produces the protein called tumour…

Q: What is the difference between Prima-1 and nutlins in the way they would fight cancer?

A: Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread…

Q: Describe the common signal transduction event that is perturbed by cancer-promoting mutations in the…

A: Neurofibromatosis type 1 (NF1) is a genetic disorder that runs in families. Peripheral…

Q: If a particular proto-oncogene has been altered by mutation into an oncogene such that it is…

A: Proto oncogenes are the genes which are inactivated in normal cell but when they get activated, it…

Q: Describe the mutational event that produces the MYC oncogene in Burkitt’s lymphoma. Why does the…

A: Burkitt lymphoma is a type of non-Hodgkin lymphoma (NHL) that affects adults and children. NHL is…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: induced pluripotent stem cells are the type of stem cells that are produced from the somatic cells…

Q: What is haploinsufficiency? How might it affect cancer risk?

A: The term in genetics that explains the function of the dominant gene in the representation of…

Q: Describe the genetic changes that convert proto-oncogenesinto oncogenes or inactivate…

A: Oncogenes can be defined as the genes which induce cancer in the organisms. These genes encode the…

Q: Why do cancer cells undergo EMT and MET? What are the cellular changes (expression or suppression of…

A: Answer

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.