You have developed an activator of a non-receptor tyrosine kinase. In three different cell types that all contain this receptor your drug has different effects. In cell type A you see activation of gene X and gene Y; in cell type B you note activation of Gene X, but no change in the mRNA levels for Gene Y. In cell type C your drug has no effect on either Gene X or Y. Describe how could each choice (A-D) be a possibility to suit the scenario? a. Genes X & Y are controlled by two separate STATs (STAT X & STAT Y). Cell type A contains both STATs; cell type B contains STAT X only; cell type C has neither STAT. b. Genes X & Y are controlled by two separate STATs (STAT X & STAT Y) and two separate JAKs (JAK X & JAK Y). Cell type A contains both STATs and JAKs; cell type B contains both STATs but JAK X only; cell type C has both STATs but neither JAK. c. Genes X & Y are controlled by two separate STATs (STAT X & STAT Y), two separate JAKs (JAK X & JAK Y) and two separate receptor heterodimers (RI/RIIx & RI/RIIy). Cell type A contains both STATs, JAKs and receptor heterodimers; cell type B contains both STATs and both JAKs but RI/RIIx only; cell type C has both STATs and both JAKs, but neither receptor heterodimer. d. All cell types contain full complement of STATs, JAKs and receptor heterodimers. Genes X & Y are controlled by different co-activators (Co-X & Co-Y). Cell type A contains both co-activators; cell type B has Co-X only; and cell type C has neither co-activator. e. a&c f. b&d g. all of the above h. none of the above
You have developed an activator of a non-receptor tyrosine kinase. In three different cell types that all contain this receptor your drug has different effects. In cell type A you see activation of gene X and gene Y; in cell type B you note activation of Gene X, but no change in the mRNA levels for Gene Y. In cell type C your drug has no effect on either Gene X or Y. Describe how could each choice (A-D) be a possibility to suit the scenario?
a. Genes X & Y are controlled by two separate STATs (STAT X & STAT Y). Cell type A contains both STATs; cell type B contains STAT X only; cell type C has neither STAT.
b. Genes X & Y are controlled by two separate STATs (STAT X & STAT Y) and two separate JAKs (JAK X & JAK Y). Cell type A contains both STATs and JAKs; cell type B contains both STATs but JAK X only; cell type C has both STATs but neither JAK.
c. Genes X & Y are controlled by two separate STATs (STAT X & STAT Y), two separate JAKs (JAK X & JAK Y) and two separate receptor heterodimers (RI/RIIx & RI/RIIy). Cell type A contains both STATs, JAKs and receptor heterodimers; cell type B contains both STATs and both JAKs but RI/RIIx only; cell type C has both STATs and both JAKs, but neither receptor heterodimer.
d. All cell types contain full complement of STATs, JAKs and receptor heterodimers. Genes X & Y are controlled by different co-activators (Co-X & Co-Y). Cell type A contains both co-activators; cell type B has Co-X only; and cell type C has neither co-activator.
e. a&c
f. b&d
g. all of the above
h. none of the above
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