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Cardiopulmonary Anatomy & Physiolo...

7th Edition
Des Jardins + 1 other
ISBN: 9781337794909

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BuyFindarrow_forward

Cardiopulmonary Anatomy & Physiolo...

7th Edition
Des Jardins + 1 other
ISBN: 9781337794909
Textbook Problem

Case 1

Why did PPHN develop in the infant in this case? How did this condition improve?

Summary Introduction

To review:

The reason behind the development of PPHN in the infant and the way through which this condition might improve.

Introduction:

PPHN (persistent hypertension of the newborn) can be defined as the failure of circulatory transition just after birth. This is characterized by pulmonary hypertension. PPHN is associated with systemic hypotension, cyanosis, meconium staining, low Apgar score, loud second heart sound, respiratory acidosis, and asphyxia.

Please refer to Clinical Application Case-1 for further information.

Explanation

The ductus arteriosus constricts in response to the increased PO2. For the closure of the ductus arteriosus, the PO2 of the infant needs to be more than 45 to 50 mm Hg (millimeter of mercury). Normally, the ductus arteriosus closes, it forms a fibrous cord known as ligament arteriosum.

In case such a level is not reached in the newborn, the ductus arteriosus remains open

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