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Biochemistry

9th Edition
Mary K. Campbell + 2 others
Publisher: Cengage Learning
ISBN: 9781305961135

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BuyFindarrow_forward

Biochemistry

9th Edition
Mary K. Campbell + 2 others
Publisher: Cengage Learning
ISBN: 9781305961135
Chapter 10, Problem 39RE
Textbook Problem
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REFLECT AND APPLY Can methylation of nucleotides play a role in DNA replication? If so, what sort of role?

Interpretation Introduction

Interpretation:

The role of methylation of nucleotides in DNA replication is to be discussed.

Concept introduction:

DNA (deoxyribonucleic acid) involves the addition of a methyl group to the DNA molecule and it can change the activity of that DNA segment without changing the sequence.

Gene transcription is repressed when the methylation occurs in the promoter region. The methylation is very important for the normal development of an individual.

Explanation of Solution

The DNA damage is recognized with the help of exonuclease enzymes usually, but when these damages escape the normal exonuclease activities of DNA polymerases I and II, the prokaryotes use other repair mechanisms.

The mismatch repair involves enzymes that have the ability to recognize that two bases are incorrectly base-paired. Now, there is a challenge for the repair systems to find out which strand is the correct one, and the correct one is identified by the methylation of DNA sequences by the prokaryotes after the replication process.

The example for this is a bacterial species that has methylated adenines and is a part of the unique sequence...

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Chapter 10 Solutions

Biochemistry
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Ch. 10 - RECALL Compare and contrast the properties of the...Ch. 10 - REFLECT AND APPLY Define processivity, and...Ch. 10 - REFLECT AND APPLY Comment on the dual role of the...Ch. 10 - REFLECT AND APPLY What is the importance of...Ch. 10 - REFLECT AND APPLY DNA synthesis always takes place...Ch. 10 - REFLECT AND APPLY What would happen to the...Ch. 10 - REFLECT AND APPLY Suggest a reason for the rather...Ch. 10 - REFLECT AND APPLY Why is it not surprising that...Ch. 10 - REFLECT AND APPLY Is it unusual that the -subunits...Ch. 10 - RECALL List the substances required for...Ch. 10 - RECALL Describe the discontinuous synthesis of the...Ch. 10 - RECALL What are the functions of the gyrase,...Ch. 10 - RECALL Single-stranded regions of DNA are attacked...Ch. 10 - RECALL Describe the role of DNA ligase in the...Ch. 10 - RECALL What is the primer in DNA replication?Ch. 10 - REFLECT AND APPLY How does the replication process...Ch. 10 - REFLECT AND APPLY Why is a short RNA primer needed...Ch. 10 - RECALL What are the common features of all DNA...Ch. 10 - RECALL What was the recent change in the estimated...Ch. 10 - RECALL What experiments led to the change in our...Ch. 10 - RECALL Why is a clamp loader necessary in...Ch. 10 - RECALL How does proofreading take place in the...Ch. 10 - RECALL Does proofreading always take place by the...Ch. 10 - RECALL Describe the excision repair process in...Ch. 10 - BIOCHEMICAL CONNECTIONS Of what benefit is it for...Ch. 10 - REFLECT AND APPLY Your book contains about 2...Ch. 10 - REFLECT AND APPLY E. coli incorporates...Ch. 10 - REFLECT AND APPLY Given the typing speed from...Ch. 10 - REFLECT AND APPLY Can methylation of nucleotides...Ch. 10 - REFLECT AND APPLY How can breakdown in DNA repair...Ch. 10 - BIOCHEMICAL CONNECTIONS Can prokaryotes deal with...Ch. 10 - RECALL What is a direct way of repairing...Ch. 10 - RECALL What proteins are used in NHEJ?Ch. 10 - RECALL Why is NHEJ an error-prone mechanism?Ch. 10 - RECALL What is the role of Ku70/80 in direct...Ch. 10 - RECALL What is homologous recombination?Ch. 10 - RECALL How did Messelson and Weigle demonstrate...Ch. 10 - REFLECT AND APPLY How has the use of DNA labeled...Ch. 10 - RECALL What is the Holliday Model?Ch. 10 - RECALL Do eukaryotes have fewer origins of...Ch. 10 - RECALL How does DNA replication in eukaryotes...Ch. 10 - RECALL What role do histones play in DNA...Ch. 10 - REFLECT AND APPLY (a) Eukaryotic DNA replication...Ch. 10 - REFLECT AND APPLY How do the DNA polymerases of...Ch. 10 - REFLECT AND APPLY What is the relationship between...Ch. 10 - BIOCHEMICAL CONNECTIONS What would be the effect...Ch. 10 - REFLECT AND APPLY Would it be advantageous to a...Ch. 10 - REFLECT AND APPLY What are replication licensing...Ch. 10 - REFLECT AND APPLY Is DNA synthesis likely to be...Ch. 10 - REFLECT AND APPLY Outline a series of steps by...Ch. 10 - BIOCHEMICAL CONNECTIONS Name an important...Ch. 10 - REFLECT AND APPLY Why is it reasonable that...Ch. 10 - BIOCHEMICAL CONNECTIONS What is meant by the RNA...Ch. 10 - BIOCHEMICAL CONNECTIONS Why are scientists excited...

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