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Questions 7 to 11 refer to a hypothetical metabolic disease in which protein E is not produced. Lack of protein E causes intellectual disability in humans. Protein E’s function is not known, but it is found in all cells of the body. Skin cells from eight individuals who cannot produce protein E were taken and grown in culture. The defect in each of the individuals is the result of a single recessive mutation. Each individual is homozygous for her or his mutation. The cells from one individual were grown with the cells from another individual in all possible combinations of the two. After a few weeks of growth, the mixed cultures were assayed for the presence of protein E. The results are given in the following table. A plus sign means that the two cell types produced protein E when grown together (but not separately); a minus sign means that the two cell types still could not produce protein E. a. Which individuals seem to have the same defect in protein-E production? b. If individual 2 married individual 3, would their children be able to make protein E? c. If individual 1 married individual 6, would their children be able to make protein E?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 10, Problem 7QP
Textbook Problem
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Questions 7 to 11 refer to a hypothetical metabolic disease in which protein E is not produced. Lack of protein E causes intellectual disability in humans. Protein E’s function is not known, but it is found in all cells of the body. Skin cells from eight individuals who cannot produce protein E were taken and grown in culture. The defect in each of the individuals is the result of a single recessive mutation. Each individual is homozygous for her or his mutation. The cells from one individual were grown with the cells from another individual in all possible combinations of the two. After a few weeks of growth, the mixed cultures were assayed for the presence of protein E. The results are given in the following table. A plus sign means that the two cell types produced protein E when grown together (but not separately); a minus sign means that the two cell types still could not produce protein E.

Chapter 10, Problem 7QP, Questions 7 to 11 refer to a hypothetical metabolic disease in which protein E is not produced. Lack

  1. a. Which individuals seem to have the same defect in protein-E production?
  2. b. If individual 2 married individual 3, would their children be able to make protein E?
  3. c. If individual 1 married individual 6, would their children be able to make protein E?

a.

Summary Introduction

To determine: The individuals that have same defect in protein – E production.

Introduction: Production of proteins is controlled by the genetic code for that particular protein, present in the genome of that organism. Different metabolic pathways are controlled by different proteins. Synthesis of these metabolic pathway controlling proteins can be interrupted by many different reasons that are present in the pathway. Combination of genes from two different organisms can alter the effect of the genetic code for that protein based on the presence of alleles in homozygosity or heterozygosity.

Explanation of Solution

When cells from each individual were grown in combination with cells from other individual, it was seen that the following combination of cells did not produced protein E:

Cells from individual 1 and individual 6

Cells from individual 2 and individual 7

Cells from individual 3 and individual 8...

b.

Summary Introduction

To explain: whether children born from marriage of individual 2 and individual 3 will be able to make protein E or not.

Introduction: production of proteins is controlled by the genetic code for that particular protein, present in the genome of that organism. Different metabolic pathways are controlled by different proteins. Synthesis of these metabolic pathway controlling proteins can be interrupted by many different reasons that are present in the pathway. Combination of genes from two different organisms can alter the effect of the genetic code for that protein based on the presence of alleles in homozygocity or heterozygocity

c.

Summary Introduction

To explain: whether children born from marriage of individual 1 and individual 6 will be able to make protein E or not.

Introduction: production of proteins is controlled by the genetic code for that particular protein, present in the genome of that organism. Different metabolic pathways are controlled by different proteins. Synthesis of these metabolic pathway controlling proteins can be interrupted by many different reasons that are present in the pathway. Combination of genes from two different organisms can alter the effect of the genetic code for that protein based on the presence of alleles in homozygocity or heterozygocity

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