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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 10.7, Problem 2EG
Textbook Problem
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Although sickle cell anemia is inherited as a recessive trait, are there conditions where a heterozygous carrier might show sickle cell formation?

Summary Introduction

To explain: Whether there are conditions, where a heterozygous carrier might show sickle cell anemia.

Introduction: Sickle cell anemia is a genetic disease that is inherited from one generation to next in an autosomal recessive manner. People suffering from this disease show mutations in the genes that code for the β-globin chain of hemoglobin. , This results in the formation of improperly folded hemoglobin molecule. Red blood cells of people suffering from this disease are sickle shaped.

Explanation of Solution

Sickle cell anemia is caused due to a single mutation in the gene coding for β chain of hemoglobin, where glutamic acid is replaced by valine. This disease is inherited in an autosomal recessive manner, which means, to develop the disease, presence of two copies of the recessive alleles are needed...

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