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In the gene-coding sequence shown here, which of the following events will produce a frameshift after the last mutational site? a. insertion of an A after the first codon b. deletion of the second codon (AAA) c. insertion of TA after the second codon and deletion of CG in the fourth codon d. deletion of AC in the third codon

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 11, Problem 14QP
Textbook Problem
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In the gene-coding sequence shown here, which of the following events will produce a frameshift after the last mutational site?

Chapter 11, Problem 14QP, In the gene-coding sequence shown here, which of the following events will produce a frameshift

  1. a. insertion of an A after the first codon
  2. b. deletion of the second codon (AAA)
  3. c. insertion of TA after the second codon and deletion of CG in the fourth codon
  4. d. deletion of AC in the third codon

Summary Introduction

To explain: The event which is responsible for producing frameshift mutation in the given gene sequence.

Introduction: Mutation is the change in the original nucleotide sequence of the DNA. During mutation, the nucleotide can be added, deleted, or transformed. A frameshift mutation is a mutation which changes the sequence or frame of the entire gene.

Explanation of Solution

Reason for correct answer:

A frameshift mutation occurs due to the addition or deletion of one or more nucleotides in the gene.

Option a. is given as “insertion of A after the first codon.” It will cause a change in the reading frame. The second codon will be AAA only, but the third codon will become AUA instead of UAC. So, it will change the codon sequence. Hence, the correct answer is option a.

Option d. is given as “deletion of AC in the third codon.” The first two codons will remain the same but the third codon will become UCG instead of UAC. So, it will change the codon sequence. Hence, the correct answer is option d...

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