menu
bartleby
search
close search
Hit Return to see all results
close solutoin list

Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?

BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

Solutions

Chapter
Section
BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 11, Problem 16QP
Textbook Problem
17 views

Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals):

  1.       a.            Circle the individual(s) in which the mutation most likely occurred.
  2.       b.            Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer.
  3.        c.            Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?

Chapter 11, Problem 16QP, Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior

a.

Summary Introduction

To determine: The individual in which mutation is most likely to occur.

Introduction: Mutation in RB1 gene of any individual leads to an uncommon autosomal dominant disorder known as familial retinoblastoma. Retina of the eye is most likely to be affected which results in eye cancer. Children are prominently affected.

Explanation of Solution

Pictorial representation: Fig.1 shows the individuals (circled ones) in which the mutation most likely occurred.

Fig.1: The pedigree shows the circled individuals in which mutation most likely occurred...

b.

Summary Introduction

To justify: Whether the person who is the source of mutation is affected by retinoblastoma.

Introduction: Mutation in RB1 gene of any individual leads to an uncommon autosomal dominant disorder known as familial retinoblastoma. Retina of the eye is most likely to be affected which results in eye cancer. Children are prominently affected.

c.

Summary Introduction

To explain: The chances of having an affected child from the parents affected with retinoblastoma.

Introduction: Mutation in a gene of retinoblastoma can have lethal affects. Mutation affects an individual in young age rather than in the adult age.

Still sussing out bartleby?

Check out a sample textbook solution.

See a sample solution

The Solution to Your Study Problems

Bartleby provides explanations to thousands of textbook problems written by our experts, many with advanced degrees!

Get Started

Chapter 11 Solutions

Human Heredity: Principles and Issues (MindTap Course List)
Show all chapter solutions
add

Additional Science Textbook Solutions

Find more solutions based on key concepts
Show solutions add
Translate the .sequence of bases in the previous question, starting at the second base.

Biology: The Unity and Diversity of Life (MindTap Course List)

Define homeostasis.

Human Biology (MindTap Course List)

Which is required as part of hemoglobin? iron calcium vitamin C potassium

Nutrition: Concepts and Controversies - Standalone book (MindTap Course List)

What is the major component in gallstones?

Chemistry for Today: General, Organic, and Biochemistry

True or false? Phylogeny helps us study the spread of viruses through human populations.

Biology: The Unity and Diversity of Life (MindTap Course List)

A synchronous satellite, which always remains above the same point on a planets equator, is put in orbit around...

Physics for Scientists and Engineers, Technology Update (No access codes included)

Of what commercial importance are marine algae and plants?

Oceanography: An Invitation To Marine Science, Loose-leaf Versin