To review:
The effects of the aspirin and steroids on the
Introduction:
Aspirin is also known as the acetylsalicylic acid (ASA). It is a common nonsteroidal anti-inflammatory drugs (NSAID). It functions as antipyretic, analgesic, and anti-inflammatory molecule. The steroids are a class of organic compounds havingfour rings of carbon in theirmolecular structure. The examples of steroid include vitamin, slkaloids, and hormones.
Explanation of Solution
The rheumatoid arthritis is a diseased condition thatis characterized by the inflammation of joints. It is a type of the autoimmune disease, in which autoantibodies are produced against the body’s own cells. Thetreatment of rheumatoid arthritis is done by administration of aspirin or steroids that are used to suppress the pain and inflammation.
The mode of action ofaspirin includes the suppression of inflammation and pain. It is known to block the enzymeprostaglandin synthase, which converts arachidonic acid to prostaglandins. The steroids have the different mechanism to suppress the inflammation. In the macrophages, these steroids inhibit the phospholipase A2 that is used in the production of the arachidonic acid.
The steroid blocks the phospholipase A2, which is the precursor of arachidonic acid. The aspirin blocks the process in which arachidonic acid is converted to prostaglandins. Thus, they both help in suppressing the inflammation induced by the prostaglandin, a type of eicosanoids, but the steroids are more effective as they show immediate effects but should be administered only in severe cases because of their sideeffects.
Thus, it can be concluded that the steroids and the aspirin block the pathway used in the synthesis of theprostaglandins in the body and help in the suppression of inflammation. The difference between the two is that the steroid blocks the synthesis of the phospholipase A2. As a result, arachidonic acid is not synthesize, dhich is the starting precursors for other eicosanoids. While the aspirin blocks the subsequent steps used in the production of mediators of inflammation.
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Chapter 11 Solutions
Biochemistry: The Molecular Basis of Life
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