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Chemistry & Chemical Reactivity

10th Edition
John C. Kotz + 3 others
ISBN: 9781337399074

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BuyFindarrow_forward

Chemistry & Chemical Reactivity

10th Edition
John C. Kotz + 3 others
ISBN: 9781337399074
Textbook Problem

Acetaminophen is used in analgesics. A model of the molecule is shown here with its electrostatic potential surface. Where are the most likely sites for hydrogen bonding?

images

Interpretation Introduction

Interpretation: Hydrogen bonding sites of acetaminophen has to be identified.

Concept Introduction:

A hydrogen bonding is partially an electrostatic attraction between H atom which is bonded to more electronegative atom such as N, O, orF and another adjacent atom bearing a lone pair of electron

Electrostatic potential surface illustrates the charge distributions of a molecule three dimensionally.

Explanation

The red region corresponds to the region of greatest electron density.  Among the atoms present, oxygen is most electronegative.

Non-red or blue region is the place where electron density is not intense.

Most probable site of hydrogen bonding is at

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