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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 11, Problem 5QP
Textbook Problem
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Achondroplasia is a rare dominant autosomal defect resulting in dwarfism. The unaffected brother of an individual with achondroplasia is seeking counsel on the likelihood of his being a carrier of the mutant allele. What is the probability that the unaffected client is carrying the achondroplasia allele?

Summary Introduction

To explain: The probability of an individual being a carrier of achondroplasia allele if the sibling of the individual is suffering from the achondroplasia condition.

Introduction:  Achondroplasia is the condition of the autosomal dominant defect, which results in dwarfism. It affects the cartilage formation in the individual which blocks the development of bones.

Explanation of Solution

Autosomal dominant alleles are expressed in every generation of the affected individual because allele is dominant in its expression. In the given case, a mutation in the achondroplasia gene of an affected individual appeared suddenly with no previous history of the condition. Sibling of the affected individual is unaffected with the condition...

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