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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 12, Problem 11QP
Textbook Problem
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Describe the likelihood of developing bilateral (both eyes affected) retinoblastoma in the inherited versus the sporadic form of the disease.

Summary Introduction

To describe: The likelihood of developing bilateral retinoblastoma in the inherited versus the sporadic form of the disease.

Introduction: Retinoblastoma is a rare form of cancer and occurs due to a mutation in the tumor-suppressing gene. The inherited form of cancer is defined as cancer in which the mutated genes for cancer are transmitted to the next generation. The sporadic form of cancer develops during the lifetime of a person and the genes for the cancer are not inherited.

Explanation of Solution

The hereditary form of cancer is responsible for bilateral retinoblastoma. Bilateral retinoblastoma is caused due to a mutation in the RB1 gene. This gene is normally responsible for regulating cell division, but a mutation in these genes leads to cancerous property in the cells. In this case, the gene mutation occurs during the early development of the fetus in the womb...

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