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The parents of a 1-year-old boy are concerned that their son may be susceptible to retinoblastoma because the father’s brother had bilateral retinoblastoma. Both parents are normal (no retinoblastoma). They have their son tested for the RB gene and find that he has inherited a mutant allele. The father is tested and is found to carry a mutant allele. a. Why didn’t the father develop retinoblastoma? b. What is the chance that the couple will have another child carrying the mutant allele? c. Is there a benefit to knowing that their son may develop retinoblastoma?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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Chapter
Section
BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 12, Problem 12QP
Textbook Problem
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The parents of a 1-year-old boy are concerned that their son may be susceptible to retinoblastoma because the father’s brother had bilateral retinoblastoma. Both parents are normal (no retinoblastoma). They have their son tested for the RB gene and find that he has inherited a mutant allele. The father is tested and is found to carry a mutant allele.

  1. a. Why didn’t the father develop retinoblastoma?
  2. b. What is the chance that the couple will have another child carrying the mutant allele?
  3. c. Is there a benefit to knowing that their son may develop retinoblastoma?

a.

Summary Introduction

To determine: The reason behind the father not developing retinoblastoma.

Introduction: Cancer is defined as the condition in which the cells start showing abnormal and uncontrolled growth. The main cause of this condition is due to the mutation in cells. These mutations affect the contact inhibition amongst cells. Retinoblastoma is cancer of eyes in which the retinoblast cells grow uncontrollably.

Explanation of Solution

Retinoblastoma shows homozygous expression, for a person to be affected by retinoblastoma both the RB1 genes must be mutated. Since the father was carrying only a single mutated RB1 ...

b.

Summary Introduction

To determine: The chance that the couple will have another child carrying the mutant allele.

Introduction: The hereditary form of cancer is responsible for bilateral retinoblastoma. Bilateral retinoblastoma is caused due to a mutation in the RB1 gene. This type of cancer occurs due to a mutation in the tumor-suppressing gene and the homozygous condition is required for cancer to occur

c.

Summary Introduction

To determine: Whether there a benefit to knowing that the son in the given case may develop retinoblastoma.

Introduction: The hereditary form of cancer is responsible for bilateral retinoblastoma. Bilateral retinoblastoma is caused due to a mutation in both the RB1 genes in a person. This type of cancer occurs due to a mutation in the tumor-suppressing gene and the homozygous condition is required for cancer to occur

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