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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 12, Problem 16QP
Textbook Problem
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In DNA repair, how does the normal allele of BRCA1 work?

Summary Introduction

To describe:  The role of normal allele of BRCA1 in DNA repair.

Introduction: DNA damage is defined as a condition in which, during the replication process, the base pairs are mismatched or some of the base pairs undergo mutation. It is important to rectify these mismatches as an alteration in the base pair arrangement affects the structure of the protein coded by these base pairs. The DNA repair mechanism is an important tool responsible for removing mutations from the genome during the process of DNA synthesis.

Explanation of Solution

BRCA1 act as a mediator of the DNA repair mechanism. BRCA1 is a tumor-suppressing gene BRCA1 along with BRCA2 is involved in three important parts of cell division namely DNA repair, DNA damage-induced cell cycle checkpoint activation and apoptosis...

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