Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 12.5, Problem 1TQ
Summary Introduction
To review:
The effect on a toggle switch when repressor 1 and repressor 2 proteins are set at the same protein levels in the absence of an inducer.
Introduction:
Biological toggle switches control the system-biological circuits. Two repressor genes are present in the circuit and the products of these genes can repress each other's transcription. The switch depends on the position of the switches. Repressor 1 is inactivated by inducer 1 and repressor 2 is produced. The transcription ofrepressor 1 gene and the reporter gene is stopped by repressor 2.
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Students have asked these similar questions
Contrast the role of the repressor in an inducible system and in a repressible system.
In the above E. coli cell, with high glucose and low lactose levels, what happens at the operator?
low lactose causes activation of a repressor protein, allowing it to detach from the operator
low lactose causes inactivation of a repressor protein, allowing it to detach from the operator
low lactose causes activation of a repressor protein, allowing it to bind to the operator
low lactose causes inactivation of a repressor protein, allowing it to bind to the operator
all of the above
What role does an operator sequence serve in bacterial gene expression regulation?
Describe one change in bacterial cells that can cause a repressor protein to go from inactive to active or from active to inactive.
Chapter 12 Solutions
Microbiology: An Evolving Science (Fourth Edition)
Ch. 12.1 - Prob. 1TQCh. 12.1 - Prob. 2TQCh. 12.1 - Prob. 3TQCh. 12.1 - Prob. 4TQCh. 12.2 - Prob. 1TQCh. 12.2 - Prob. 2TQCh. 12.2 - Prob. 3TQCh. 12.3 - Prob. 1TQCh. 12.4 - Prob. 1TQCh. 12.4 - Prob. 2TQ
Ch. 12.5 - Prob. 1TQCh. 12 - Prob. 1RQCh. 12 - Prob. 2RQCh. 12 - Prob. 3RQCh. 12 - Prob. 4RQCh. 12 - Prob. 5RQCh. 12 - Prob. 6RQCh. 12 - Prob. 7RQCh. 12 - Prob. 8RQCh. 12 - Prob. 9RQCh. 12 - Prob. 10RQCh. 12 - Prob. 11RQCh. 12 - Prob. 12RQCh. 12 - Prob. 13RQCh. 12 - Prob. 14RQCh. 12 - Prob. 15RQCh. 12 - Prob. 1TQCh. 12 - Prob. 2TQCh. 12 - Prob. 3TQ
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- What is the effect of an increased Cro concentration on the expression of the gene for the λ repressor? Of an increased concentration of λ repressor on the expression of the Cro gene? Of an increased concentration of λ repressor on the expression of the λ repressor gene?arrow_forwardWhen taken up by a cell, which of the following molecules binds to a repressor so that the repressor no longer binds to the operator? a) inducer b) promoter c) repressor d) corepressorarrow_forwardHow would a mutation in E. coli make the lac operator unable to bind the active repressor to affect the cell?arrow_forward
- E. coli are grown on a medium containing lactose. Once glucose is added to the medium, the bacteria stop fermenting lactose. Which of the following BEST explains the observed effect? A. Cellular levels of cAMP are lowB.Glucose is bound to the promoter C. Repressor protein is bound to the operator D. Repressor protein is bound to the promoterarrow_forwarddescribe the 4 types of suppressors inducer, repressor, promoter, and operator.arrow_forwardWhat is a major difference between activator proteins and repressor proteinsarrow_forward
- A scientist identifies a potential transcription regulation site 300bp downstream of a gene and hypothesizes that it is a repressor. What experiment (with results) could he perform to support this hypothesis?arrow_forwardWhich of the following is an example of positive control? (a) transcription occurs when a repressor binds to an inducer (b) transcription cannot occur when a repressor binds to a corepressor (c) transcription is stimulated when an activator protein binds to DNA (d) a and b (e) a and carrow_forwardBinding of _______ to _______ in DNA can increase the rate of transcription of specific genes. a. activators; repressors c. repressors; operators b. activators; enhancers d. repressors; enhancersarrow_forward
- Compare and contrast the activities of an activator protein anda repressor protein.arrow_forwardDescribe the function of activators and repressors.arrow_forwardA gene in liver cells is "off". In the presence of a toxin, a repressor is removed and the gene is transcribed at low levels. How would you describe this regulation? A. Positive induction B. Negative induction C. Positive repression D. Negative repressionarrow_forward
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