Heterozygous individuals perpetuate some alleles that have lethal effects in homozygous individuals. A mutated allele (ML) associated with taillessness in Manx cats (left) is an example. Cats homozygous for this allele (MLML) typically die before birth due to severe spinal cord defects. In a case of incomplete domina.nre, cats heterozygous for the ML allele and the normal, unmutated allele (M) have a short, stumpy tail or none at all Two MLM cats mate. What is the probability that any one of their surviving kittens will be heterozygous?
To explain: The probability that one of the surviving kittens with parents having the allele MLM associated with taillessness in Manx cats will be heterozygous.
Concept introduction: The mutated ML allele is associated with taillessness in Manx cats. The homozygous MLML allele is called as lethal alleles, as they cause death of the kitten as embryo itself due to defects of the spinal cord. Lethal alleles are those in heterozygous or homozygous form that causes death of the individual during embryonic development itself. The probability reduces in such cases, as those alleles will not be transferred to the next generation as the allele is lost with the death of the embryo.
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