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G6PD deficiency is an X-Linked recessive disorder. When people who have this disorder eat fava beans, they have a dangerous acute reaction in which a large number of their red blood cells rupture. A mother has the disorder; the father does not. What is the chance that any child of this union will have the trait?

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Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332

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Chapter
Section
BuyFindarrow_forward

Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332
Chapter 14, Problem 2GP
Textbook Problem
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G6PD deficiency is an X-Linked recessive disorder. When people who have this disorder eat fava beans, they have a dangerous acute reaction in which a large number of their red blood cells rupture. A mother has the disorder; the father does not. What is the chance that any child of this union will have the trait?

Summary Introduction

To determine: The chances of child having G6PD deficiency when mother has the disorder and father does not.

Introduction:

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder caused due to the defect in glucose-6-phosphate dehydrogenase enzyme. It causes premature breakdown of red blood cells (RBCs) and may cause hemolytic anemia. It is mostly triggered by viral or bacterial infections, eating fava beans, or inhalation of pollens from fava plants. G6PD follows an X-linked recessive inheritance.

Explanation of Solution

The genes responsible for Glucose-6-phosphate dehydrogenase (G6PD) are located on the X chromosome. Males have one X and one Y chromosome, and females have two X chromosomes. As given in the problem statement, a mother has the disorder and the father is normal. As G6PD deficiency shows recessive X-linked inheritance, this means that the mother carries two copies of mutated alleles (XGXG) for G6PD deficiency on X chromosomes...

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