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The somatic cells of most individuals with Down syndrome contain an extra chromosome 21, for a total of forty-seven chromosomes. a. At which stage(s) or meiosis could nondisjunction alter the chromosome number? b. A few individuals with Down syndrome have forty-six chromosomes: two normal-appearing chromosomes 21, and a longer-than-normal chromosome 14. Speculate on how this chromosome abnormality may arise.

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Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332

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Chapter
Section
BuyFindarrow_forward

Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332
Chapter 14, Problem 8GP
Textbook Problem
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The somatic cells of most individuals with Down syndrome contain an extra chromosome 21, for a total of forty-seven chromosomes.

  1. a. At which stage(s) or meiosis could nondisjunction alter the chromosome number?
  2. b. A few individuals with Down syndrome have forty-six chromosomes: two normal-appearing chromosomes 21, and a longer-than-normal chromosome 14. Speculate on how this chromosome abnormality may arise.

a.

Summary Introduction

To determine: The stage of meiosis at which nondisjunction alter the chromosome number and cause Down syndrome.

Introduction: Down syndrome is a genetic disorder caused by trisomy of chromosome 21. This results due to a random cell division error is known as nondisjunction. The errors occur mostly during the formation of gametes, the majority comes from mother in the egg. Three types of chromosomal abnormalities lead to Down syndrome- the complete trisomy 21, mosaic trisomy 21, and translocation trisomy 21.

Explanation of Solution

Most of the individuals suffering from Down syndrome have an extra chromosome 21 and total forty-seven chromosomes. During the cell division, the chromosome pairs are split and each pair goes to different cells. This occurs during anaphase I or anaphase II of meiosis...

b.

Summary Introduction

To determine: How some individuals with Down syndrome have forty-six chromosomes including two normal chromosomes 21 and a longer than normal chromosome 14.

Introduction: Down syndrome is a genetic disorder caused by trisomy of chromosome 21. This results due to a random cell division error is known as nondisjunction. The errors occur mostly during the formation of gametes, the majority comes from mother in the egg. Three types of chromosomal abnormalities lead to Down syndrome- the complete trisomy 21, mosaic trisomy 21, and translocation trisomy 21.

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