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Mutations in the genes for clotting factor VIII and IX cause hemophilia A and B, respectively. A Woman may be heterozygous for mutations in both genes with a mutated factor VIII allele on one X chromosome, and a mutated factor IX allele on the other. All or her sons should have either hemophilia A or B. However, on rare occasions, one of these women gives birth to a son who does not have hemophilia, and his one X chromosome does not have either mutated allele. Explain.

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Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332

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Section
BuyFindarrow_forward

Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332
Chapter 14, Problem 9GP
Textbook Problem
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Mutations in the genes for clotting factor VIII and IX cause hemophilia A and B, respectively. A Woman may be heterozygous for mutations in both genes with a mutated factor VIII allele on one X chromosome, and a mutated factor IX allele on the other. All or her sons should have either hemophilia A or B. However, on rare occasions, one of these women gives birth to a son who does not have hemophilia, and his one X chromosome does not have either mutated allele. Explain.

Summary Introduction

To determine: How the son of a woman heterozygous for mutations in genes causing hemophilia A and B did not have any mutated allele on X chromosome and was normal.

Introduction:

Hemophilia is a genetic disorder characterized by impaired ability to form blood clot. It is due to mutation in genes encoding clotting factors VIII and IX, causing two types of hemophilia- A and B, respectively. It follows X-linked inheritance pattern. Males have one X chromosome and females have two X chromosomes. If females carry the mutated gene on one of her X chromosome, she will be a carrier. She can pass the allele to her son.

Explanation of Solution

As given in the problem statement, women may be heterozygous for mutations in both the genes with a factor VIII mutated allele on one X chromosome and factor IX mutated allele on other X chromosome. Since, hemophilia has X-linked inheritance, all sons of these women must have either hemophilia A or B. It is given that on some rare occasion, one of these women gave birth to a normal male child who does not have hemophilia. His X chromosome does not have either of the mutated allele causing hemophilia...

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