Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 15, Problem 12QP
One unexpected result of the sequencing of the human genome was the finding that mutations in a single gene can be responsible for multiple distinct disorders. For example, mutations in the RET gene can cause two different types of multiple endocrine neoplasias, familial medullary thyroid carcinoma, and Hirschsprung disease. How do you think mutations in a single gene can have such diverse effects?
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One unexpected result of the sequencing of the human genome was the finding that mutations in a single gene can be responsible for multiple distinct disorders. How do you think mutations in a single gene can have such diverse effects?
Gene mutations can be classified in two major ways:(1) hereditary or germline mutations that are inherited from a parent and are present throughout a person’s life in virtually every cell in the body.(2) acquired or somatic mutations that occur at some time during a person’s life and are present only in certain cells, not in every cell in the body.If there is no family history of a particular disease but a child has the disease then it may have arisen due to a(n) ________ mutation early during development.
A) acquired
B) inherited
C) silent
D) transition
In order to manufacture insulin for patients with diabetes, scientists create recombinant DNA by inserting a human insulin gene into bacterial DNA and have the bacteria produce human insulin. Based on what you have learned in this unit about gene expression, what must the scientists do to the DNA sequence of the human insulin gene BEFORE inserting it into the bacteria, in order to have them produce the same insulin sequence that humans would produce? Explain.
Chapter 15 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 15.1 - Who Owns Your Genome? John Moore, an engineer...Ch. 15.1 - Who Owns Your Genome? John Moore, an engineer...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - James sees an online ad for an at-home genetic...Ch. 15 - The gene controlling ABO blood type and the gene...Ch. 15 - Hemophilia and color blindness are both recessive...Ch. 15 - Prob. 3QPCh. 15 - Prob. 4QP
Ch. 15 - How many nucleotides does the human genome...Ch. 15 - Which of the following best describes the process...Ch. 15 - Which of the following is NOT an activity carried...Ch. 15 - Prob. 8QPCh. 15 - Prob. 9QPCh. 15 - What percentage of the DNA in the genome actually...Ch. 15 - When the human genome sequence was finally...Ch. 15 - One unexpected result of the sequencing of the...Ch. 15 - Prob. 13QPCh. 15 - Prob. 14QPCh. 15 - Prob. 15QPCh. 15 - Prob. 16QPCh. 15 - Prob. 17QP
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Although it is well known that X-rays cause mutations, they are routinely used to diagnose medical problems, including potential tumors, broken bones, and dental cavities. Why is this done? What precautions need to be taken?arrow_forwardWhen the human genome sequence was finally completed, scientists were surprised to discover that the genome contains far fewer genes than expected. How many genes are present in the human genome? Scientists have also found that there are many more different kinds of proteins in human cells than there are different genes in the genome. How can this be explained?arrow_forwardDNA sequencing has provided data to indicate that cancer cells may contain tens of thousands of somatic mutations, only some of which confer a growth advantage to a cancer cell. How do scientists describe and categorize these recently discovered populations of mutations in cancer cells?arrow_forward
- At the molecular level, how do you think a gain-of-function mutation in a developmental gene might cause it to be expressed in the wrong place or at the wrong time? Explain what type of DNA sequence would be altered.arrow_forwardWhich among the following statements is not true about mutations? * a.) It may either occur at the chromosomes or at the sequence of nucleic acids. b.) It is caused either by mutagens or through hereditary genes. c.) All mutations cause diseases and disorders in the developing organism. d.) All mutations causes a change in the structure or sequence of the genetic material.arrow_forwardHow might a point mutation in DNA affect the phenotype. How the genome is expressed in the organism? (Please explain this at the molecular level).arrow_forward
- Which, if any, of the following statements is false? a) Most of the inherited changes in our DNA arise because of exposure to extracellular mutagens, including radiation sources and chemical mutagens. b) Most of the inherited changes in our DNA arise because of unavoidable endogenous errors in cellular mechanisms and harmful effects of certain natural molecules and atoms within our cells. c) Errors in DNA replication and DNA repair are a major source of mutations in our cells. d) Significant chemical damage is sustained by DNA because of its proximity to water molecules in our cells.arrow_forwardWhat is a heterochronic mutation? How does it affect the phenotypic outcome of an organism? What phenotypic effects would you expect if a heterochronic mutation affected the cell lineage that determines the fates of intestinal cells?arrow_forwardAre mutations equally likely to occur in all locations in the genome? Why or why not?arrow_forward
- In contrast with the genomic manipulations of animals and plants described in this chapter, human genetherapy is directed specifically at altering the genomes of somatic cells rather than germ-line cells.Why couldn’t or wouldn’t medical scientists try to alter the genome of human germ-line cells?arrow_forwardIn McCune-Albright syndrome, fibrous connective tissue replaces bone, tan patches (café-au-lait spots) dot the skin, and hormone abnormalities cause early puberty and malfunction of the thyroid, pituitary, and adrenal glands. The phenotype is highly variable, and all patients are somatic mosaics for the mutation, which is in the gene GNAS1. Why is the condition seen only in mosaics?arrow_forwardResearchers have identified a gene in humans that (when mutated) causes tremors and unstable walking due to neurological problems. This disorder is inherited in an autosomal recessive manner, and the mutant allele isknown to result from a loss-of-function mutation. The same gene hasbeen found in mice, although a mutant mouse version has not beendiscovered. To develop an effective drug therapy to treat this disorderin humans, it would be experimentally useful to have a mouse model.In other words, it would be desirable to develop a strain of mice thatcarry the mutant allele in the homozygous condition. How would youdevelop such a strain?arrow_forward
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