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You join a laboratory that studies a rare genetic disorder that causes affected individuals to have unusually fast-growing, bright green hair. You are joining the lab at a fortuitous moment, as the gene causing the disorder has just been cloned. Despite this breakthrough, however, it is still unclear what the function of the gene is, and the lab director asks you for suggestions about how to go about trying to determine this. What do you recommend?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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Chapter
Section
BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 15, Problem 14QP
Textbook Problem
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You join a laboratory that studies a rare genetic disorder that causes affected individuals to have unusually fast-growing, bright green hair. You are joining the lab at a fortuitous moment, as the gene causing the disorder has just been cloned. Despite this breakthrough, however, it is still unclear what the function of the gene is, and the lab director asks you for suggestions about how to go about trying to determine this. What do you recommend?

Summary Introduction

To determine: The methods to determine the function of a gene that has been cloned.

Introduction: For the study of a genetic disorder, scientists must know the location of the gene and the normal function of the protein encoded by this gene. The other essential point is to know about the mutant gene or protein that produces the disease phenotype.

Explanation of Solution

The methods to determine the function of a gene that an individual would suggest in the given case are as follows:

  • • The amino acid sequence of the cloned gene can be compared with the amino acid sequence of variously known amino acids. This comparison can be done by using bioinformatics.
  • • Use of structural genomics can help to determine the three-dimensional structure of proteins from their amino acid sequences...

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