Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 16.2, Problem 1COMQ
For the Igf2 gene, where do de novo methylation and maintenance methylation occur?
a. De novo methylation occurs in sperm, and maintenance methylation occurs in egg cells.
b. De novo methylation occurs in egg cells, and maintenance methylation occurs in sperm cells.
c. De novo methylation occurs in sperm, and maintenance methylation occurs in somatic cells of offspring.
d. De novo methylation occurs in egg cells, and maintenance methylation occurs in somatic cells of offspring.
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Give typing answer with explanation and conclusion
What characteristics of the DSX protein enable the female- and male-specific isoforms of DSX to regulate the same genes but with different outcomes in female and male development? [multiple answers possible]
A.The two isoforms are different alleles of the same gene
B.The two isoforms have different DNA-binding domains
C.The two isoforms are lncRNAs involved in dosage compensation
D.The two isoforms differ in their activation domain
E.The two isoforms share the same activation domain
F. The two isoforms share the same DNA-binding domain
Explain how DNA methylation and the formation of a DNA loop control the expression of the Igf2 gene in mammals. How is this gene imprinted so that only the paternal copy is expressed in offspring?
(a) Describe how dna binding proteins contact the dna
(b)How does the acetylation of lysines on the N-terminal tails of histones influences gene expression?
Chapter 16 Solutions
Genetics: Analysis and Principles
Ch. 16.1 - Which of the following are examples of molecular...Ch. 16.1 - 2. An epigenetic modification to a specific gene...Ch. 16.1 - Prob. 3COMQCh. 16.1 - Epigenetic changes may a. be programmed during...Ch. 16.2 - 1. For the Igf2 gene, where do de novo methylation...Ch. 16.2 - 2. For XCI to occur, where are the Xist and Tsix...Ch. 16.2 - 3. Which of the following possibilities could...Ch. 16.3 - 1. Which of the following statements about...Ch. 16.3 - The effects of paramutation may vary with regard...Ch. 16.4 - 1. When mice carrying theallele exhibit a darker...
Ch. 16.4 - 2. If the VIN3 gene had a loss-of-function...Ch. 16.5 - Prob. 1COMQCh. 16.5 - Prob. 2COMQCh. 16 - Prob. 1CONQCh. 16 - List and briefly describe five types of molecular...Ch. 16 - Prob. 3CONQCh. 16 - What is the key difference between cis and...Ch. 16 - Prob. 5CONQCh. 16 - Prob. 6CONQCh. 16 - 7. Outline the molecular steps in the process of...Ch. 16 - Prob. 8CONQCh. 16 - 9. In general, explain how epigenetic...Ch. 16 - 10. What are the contrasting roles of trithorax...Ch. 16 - Describe the molecular steps by which polycomb...Ch. 16 - Prob. 12CONQCh. 16 - Using coat color in mice and the development of...Ch. 16 - How can environmental agents that do not cause...Ch. 16 - Prob. 15CONQCh. 16 - Prob. 16CONQCh. 16 - Explain how the VIN3/PRC2 complex specifically...Ch. 16 - Prob. 1EQCh. 16 - In the experiments described in Figure 16.8,...Ch. 16 - Prob. 3EQCh. 16 - A research study indicated that an agent in...Ch. 16 - Lets suppose you were interested in developing...Ch. 16 - Prob. 6EQCh. 16 - Prob. 7EQCh. 16 - 2. Discuss the similarities and differences of...
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- Explain how DNA methylation could be used to regulate gene expression in a tissue-specific way. When and where would de novo methylation occur, and when would demethylation occur? What would occur in the cells that give rise to eggs and sperm?arrow_forwardA. Which genes could be used to monitor the process of the disease? B.  If you worked for a drug company developing a treatment for the cancer, which genes would you target to turn on in cancer cells? C. Which genes would you target to turn off in cancer cells?arrow_forwardDescribe the role of DNA methylation in gene expression in mammalian cells.arrow_forward
- a) What is a gene promoter? b) What proteins bind to a promoter? c) What do those proteins do to control gene expression?arrow_forwardIn one cell, gene C is expressed, whereas in another cell, geneC is inactive. After the cells are fused experimentally, both copiesof gene C are expressed. This observation could be explained bya. a cis-epigenetic mechanism.b. a trans-epigenetic mechanism.c. DNA methylation.d. both a and b.arrow_forwardExplain how DNA methylation can regulate gene expression in a tissue-specific way. When and where would de novo methylation occur,and when would demethylation occur? What would occur in the cellsthat give rise to eggs and sperm?arrow_forward
- With the understanding of DNA methylation and gene expression, answer these following questions with as little word as possible. a. What is the difference between a CpG Island vs a CpG-poor region of the genome? b. What is the typical effect of 5mCpG on gene expression, and what two classes of DNA sequences are most heavily methylated? c. What is sex-specific genomic imprinting? Cite at least one example with the given example. d. What is the main function of HOX genes: specifically, the ANT-C vs. the BX-C clusters?arrow_forwardA. In what year was the National Bioethics Advisory Council formed? B. The first mammal clone to be produced from an adult (somatic cell)?arrow_forwardWhy is regulating transcription the main way that cells control gene expression? A. Because transcription is the last step in gene expression, stopping here ensures that the cell has a stockpile of proteins to prepare them from all unexpected environmental changes. B. Because transcription involves interactions with DNA, preventing transcription reduces the changes of mutation in the cell’s genome. C. Because transcription is the first step in gene expression, stopping at transcription reduces the amount of energy and resources used by producing unnecessary gene products. D. Because transcription is the shortest step in gene expression, preventing transcription has little effect on the rate of protein production.arrow_forward
- Suggest a direct experiment to prove that p53 binding at gene promoters affects the level of gene expression of the corresponding genes.arrow_forwardEpigenetic marks regulate gene expression. Which epigenetic mark is NOT associated with positive gene expression? A. Histone acetylation B. Histone Methylation C. De-methylated DNA D. Methylated DNAarrow_forwardA mutation occurs in a gene, resulting in it being expressed at the wrong time during development. Where is the mutation most likely to be found? a) In the transcription start site (TSS) b) In a TF binding site in the cis-regulatory region c) In the coding sequence d) In the 5' UTRarrow_forward
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