Concept explainers
Interpretation:
The observation that Friedel-Crafts alkylations often give polysubstituted products but Friedel-Crafts acylations do not is to be explained.
Concept introduction:
Friedal-Crafts reaction is an electrophilic substitution reaction in which an
To explain:
The observations that Friedel-Crafts alkylation reactions give polysubstituted products but Friedel-Crafts acylations do not.
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Chapter 16 Solutions
Organic Chemistry
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- Show the interconversion of the functional group and where the compound disconnects (show where the disconnection occurs). And show the donor synthone and acceptor synthone and the appropriate reagents for the compoundarrow_forwardName and Draw the structures of all possible chemical (Electrophilic aromatic substitution) reactions of the compound namely; Halogenation (Chlorination or Bromination) Nitration Sulphonation Friedal Craft Alkylation Friedal Craft Acylationarrow_forwardCarboxylic acids contain carbonyl group but do not show the nucleophilic addition reaction like aldehydes or ketones. Why?arrow_forward
- Which one of these molecules can be a reactant in a Friedel-Crafts reaction? and why? a) Anilineb) Benzenesulfonic acidc) Chloroethened) Bromobenzenee) p-Bromonitrobenzenearrow_forwardDefine the Reaction of Organometallic Reagents with Other Compounds ?arrow_forwardIn an electrophilic aromatic substitution: Friedel-Crafts alkylation, where the tert.-butyl cation is used to alkylate 1,4-dimethoxybenzene.arrow_forward
- In the Gatterman-Koch reaction, a formyl (- CHO) group is introduced directly onto a benzene ring. For example reaction of toluene with CO and in the presence of mixed CuClAlCl 2 gives p-methylbenzaldehyde. Propose a structure for the reactive electrophile.arrow_forwardWhy can aniline not be brominated directly to 4-bromoaniline?arrow_forwardWhy are H3PO4 and H2SO4 used in the synthesis of 4-methylcyclohexene from 4-methylcyclohexanol and not HBr or HCl?arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning