Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 17, Problem 14P
Interpretation Introduction
Interpretation:
To explain a reasonable mechanism for the conversion of ethanol to acetaldehyde.
Introduction:
Alcohol Dehydrogenase is an oxidoreductase enzyme present in the cytosol of stomach and liver cells which is capable of converting alcohol into acetaldehyde via oxidation while reducing NAD+ molecule (co factor) into NADH. During catabolism when substrates such as carbohydrates, fats and etc. are subjected to oxidative reactions the energy is usually released as hydride ions and in ethyl alcoholthe carbon atom which has a hydroxyl group attached is comparatively in a more reduced state, which makes it a substrate with more chemical energy.
Expert Solution & Answer
Trending nowThis is a popular solution!
Students have asked these similar questions
Alcohol dehydrogenase catalyzes the oxidation of an alcohol to the next highest state of oxidation, an aldehyde. How does this partially explain the toxicity of methanol?
Which of the following statements inaccurately describes glutamate dehydrogenase?
Glutamate dehydrogenase uses either NAD+ or NADP+ in a redox reaction
Glutamate dehydrogenase catalyzes an oxidative deamination reaction
Glutamate dehydrogenase equilibrium lies with the reductive amination of glutamate
Glutamate dehydrogenase utilizes hydrolysis to release ammonium from an imine intermediate
Mercuric ion and methanol are inhibitors of alcohol dehydrogenase. Explain.
Chapter 17 Solutions
Biochemistry
Ch. 17 - Global Carbon Dioxide Cycling Expressed as Human...Ch. 17 - Prob. 2PCh. 17 - Where Do the O Atoms in Organisms Come From? Name...Ch. 17 - How Do Catabolism and Anabolism Differ? What are...Ch. 17 - How Art the Enzymes of Metabolic Pathways...Ch. 17 - Why Do Anabolic and Catabolic Pathways Differ? Why...Ch. 17 - Prob. 7PCh. 17 - How Is Metabolism Regulated? (Integrates with...Ch. 17 - Prob. 9PCh. 17 - Prob. 10P
Ch. 17 - Which Is “Better: NMR or MS? Compare and...Ch. 17 - How Do Vitamin-Derived Coenzymes Aid Metabolism?...Ch. 17 - What Art the Features of the Series of -omes?...Ch. 17 - Prob. 14PCh. 17 - Prob. 15PCh. 17 - Prob. 16PCh. 17 - Prob. 17PCh. 17 - Prob. 18PCh. 17 - Which of the following experimental approaches is...Ch. 17 - Prob. 20P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Examine the ActiveModel for alcohol dehydrogenase and describe the structure and function of the catalytic zinc center.arrow_forwardBased on your knowledge of the structure of NAD+ and an assumption that coenzyme dissociation is the rate limiting step of the alcohol dehydrogenase mechanism, hypothesize why a N249W mutation at the coenzyme binding site would increase the rate of catalysis.arrow_forwardThe metabolism of alcohol pathway is showed in the figure characterized by biotransformation of: (Figure : Ethanol Metabolism Pathway - ADH : Alcohol dehydrogenases, ALDH: Aldehyde dehydrogenase ) (a) reaction phase I with two oxidations (b) reaction phase II with oxidation and sulfonation (c) reaction phase II with two hydrolysations (d) reaction phase II with two oxidations (e) reaction phase I with hydrolysis and oxidationarrow_forward
- Describe the alcohol dehydrogenases of humans and S. cerevisiae. How do they differ?arrow_forwardRefer to Figure, which indicates ΔG for each glycolytic reaction under intracellular conditions. Assume that glyceraldehyde-3-phosphate dehydrogenase was inhibited with iodoacetate, which reacts with its active site cysteine sulfhydryl group. Which glycolytic intermediate would you expect to accumulate most rapidly, and why?arrow_forwardBriefly list out the chemicals contributing the anti-oxidative activities found in green tea. Apart from oxidative effect, is there any other health claims for green tea? Briefly describe one of them.arrow_forward
- What is the function of glyceraldehyde 3-phosphate dehydrogenase? catalyzes the transfer of a phosphoryl group from ATP to an acceptor oxidation of the alcohol to an aldehyde dehydration and dephosphorylation of GAP hydrolysis of GAP oxidation by NAD+ and formation of acyl-phosphatearrow_forwardDraw a plausible mechanism for the oxidative decarboxylation of isocitrate by isocitrate dehydrogenase.arrow_forwardGiven the following question, for each of the three reactions catalyzed by NADH dehydrogenase complex, identify the following1. electron donor2. electron acceptor3. the reducing agent4. the oxidizing agentarrow_forward
- In some brain cancer cells, a mutated form of isocitrate dehydrogenase, instead of catalyzing the oxidation of the secondary alcohol of isocitrate, catalyzes the reduction of a-ketoglutarate. Draw the product of the reaction.arrow_forwardWhich of the following is true about comparing the α-ketoglutarate dehydrogenase complex and the pyruvate dehydrogenase complex? Group of answer choices They catalyze reactions that produce the exact same set of products They are both dehydrogenase complexes, but have very different structures They both catalyze reactions that oxidize NADH to NAD+ They both use the same E3 enzyme component Which of the following best describes stage 2 of the citric acid cycle? Group of answer choices ATP production by the electron transport chain production of acetyl CoA regeneration of oxaloacetate release of 2 carbons as carbon dioxidearrow_forwardSelect the following enzymes that utilize a mechanism where ATP serves as the phosphate donor. Select ALL that apply: a) glyceraldehyde 3 phosphate dehydrogenase b) hexokinase c) aldolase class 1 d) PFK e) phosphoglucoisomerasearrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY