The treatment options for adenosine deaminase (ADA)-deficient severe combined immunodeficiency disease (SCID). Introduction: Mr. and Mrs. J were referred to a clinical geneticist because their 6-month-old daughter was not growing appropriately. After the examination, the doctor observed that their daughter had a constant cough, wheeze, and extensive yeast infection. The doctor also took a blood test and determined that their daughter has suffered from SCID. It was also found that their daughter had inherited mutant allele for SCID from the parents.

Question

Want to see more full solutions like this?

Answer 1

Question

Chapter 17, Problem 1CS

Summary Introduction

To determine: The treatment options for adenosine deaminase (ADA)-deficient severe combined immunodeficiency disease (SCID).

Introduction: Mr. and Mrs. J were referred to a clinical geneticist because their 6-month-old daughter was not growing appropriately. After the examination, the doctor observed that their daughter had a constant cough, wheeze, and extensive yeast infection. The doctor also took a blood test and determined that their daughter has suffered from SCID. It was also found that their daughter had inherited mutant allele for SCID from the parents.

Expert Solution & Answer

Explanation of Solution

According to the case study, both the parents have the heterozygous mutant allele for ADA deficiency. The daughter has received both the mutant alleles from both father and mother and has become homozygous for the condition. ADA-deficient SCID is an immunodeficiency disorder. This condition causes a reduction in the synthesis of immune cells. In the absence of immune cells, the person would become immunocompromised. A person with ADA-SCID would become susceptible to infections. The possible treatment of this disease can be done by medicating the person with immune-modulating drugs.

Gene therapy is also a good option for the treatment of ADA-SCID. Using gene therapy, the gene of adenosine deaminase deficiency is replaced with normal genes. This would stimulate the immune system and improve the condition of the patient. However, the success rate of gene therapy is very low. In order to prevent the patient from infections, the patient must be kept in a sterile environment. However, there is no appropriate treatment for ADA-SCID that can cure this disease.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Students have asked these similar questions

A couple is planning a family, but since each has a brother having the sickle-cell disorder, they are worried that their kids might develop the disorder too. Neither of them nor their respective parents have the disorder. Which of the following will be your smartest advice as a genetic counsellor? One of four of their children can be expected to have sickle cell. It is possible that none of their kids will have the disorder, but tests should be carried out on both of them to confirm. All of their children will have sickle-cell disorder. There is no chance of any of their kids having sickle cell.

Person A and person B are both worried they are going to develop a neurodegenerative disease. Unfortunately, person A has more reason to be worried than person B. Of the neurodegenerative disorders below, pick one and come up with one possible reason why person A is more likely to develop this disorder than person B, and also come up with one possible reason why person B is more likely to be protected from the disorder. For full credit, you must concoct TWO separate genetic, environmental, or lifestyle reasons that will make person A more likely, and person B less likely to develop the disease you’ve selected: Parkinson’s Alzheimer’s disease Huntington’s Multiple Sclerosis

As a genetic counselor, you are asked to assess the risk for a couple with a family history of familial adenomatous polyposis (FAP) who are thinking about having children. Neither the husband nor the wife has colorectal cancer, but the husband has a sister with FAP. What is the probability that this couple will have a child with FAP? Are there any tests that you could recommend to help in this assessment?

Answer 2

Question

Chapter 17, Problem 1CS

Summary Introduction

To determine: The treatment options for adenosine deaminase (ADA)-deficient severe combined immunodeficiency disease (SCID).

Introduction: Mr. and Mrs. J were referred to a clinical geneticist because their 6-month-old daughter was not growing appropriately. After the examination, the doctor observed that their daughter had a constant cough, wheeze, and extensive yeast infection. The doctor also took a blood test and determined that their daughter has suffered from SCID. It was also found that their daughter had inherited mutant allele for SCID from the parents.

Expert Solution & Answer

Explanation of Solution

According to the case study, both the parents have the heterozygous mutant allele for ADA deficiency. The daughter has received both the mutant alleles from both father and mother and has become homozygous for the condition. ADA-deficient SCID is an immunodeficiency disorder. This condition causes a reduction in the synthesis of immune cells. In the absence of immune cells, the person would become immunocompromised. A person with ADA-SCID would become susceptible to infections. The possible treatment of this disease can be done by medicating the person with immune-modulating drugs.

Gene therapy is also a good option for the treatment of ADA-SCID. Using gene therapy, the gene of adenosine deaminase deficiency is replaced with normal genes. This would stimulate the immune system and improve the condition of the patient. However, the success rate of gene therapy is very low. In order to prevent the patient from infections, the patient must be kept in a sterile environment. However, there is no appropriate treatment for ADA-SCID that can cure this disease.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 3

Question

Chapter 17, Problem 1CS

Summary Introduction

To determine: The treatment options for adenosine deaminase (ADA)-deficient severe combined immunodeficiency disease (SCID).

Introduction: Mr. and Mrs. J were referred to a clinical geneticist because their 6-month-old daughter was not growing appropriately. After the examination, the doctor observed that their daughter had a constant cough, wheeze, and extensive yeast infection. The doctor also took a blood test and determined that their daughter has suffered from SCID. It was also found that their daughter had inherited mutant allele for SCID from the parents.

Expert Solution & Answer

Explanation of Solution

According to the case study, both the parents have the heterozygous mutant allele for ADA deficiency. The daughter has received both the mutant alleles from both father and mother and has become homozygous for the condition. ADA-deficient SCID is an immunodeficiency disorder. This condition causes a reduction in the synthesis of immune cells. In the absence of immune cells, the person would become immunocompromised. A person with ADA-SCID would become susceptible to infections. The possible treatment of this disease can be done by medicating the person with immune-modulating drugs.

Gene therapy is also a good option for the treatment of ADA-SCID. Using gene therapy, the gene of adenosine deaminase deficiency is replaced with normal genes. This would stimulate the immune system and improve the condition of the patient. However, the success rate of gene therapy is very low. In order to prevent the patient from infections, the patient must be kept in a sterile environment. However, there is no appropriate treatment for ADA-SCID that can cure this disease.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 4

Question

Chapter 17, Problem 1CS

Summary Introduction

To determine: The treatment options for adenosine deaminase (ADA)-deficient severe combined immunodeficiency disease (SCID).

Introduction: Mr. and Mrs. J were referred to a clinical geneticist because their 6-month-old daughter was not growing appropriately. After the examination, the doctor observed that their daughter had a constant cough, wheeze, and extensive yeast infection. The doctor also took a blood test and determined that their daughter has suffered from SCID. It was also found that their daughter had inherited mutant allele for SCID from the parents.

Expert Solution & Answer

Explanation of Solution

According to the case study, both the parents have the heterozygous mutant allele for ADA deficiency. The daughter has received both the mutant alleles from both father and mother and has become homozygous for the condition. ADA-deficient SCID is an immunodeficiency disorder. This condition causes a reduction in the synthesis of immune cells. In the absence of immune cells, the person would become immunocompromised. A person with ADA-SCID would become susceptible to infections. The possible treatment of this disease can be done by medicating the person with immune-modulating drugs.

Gene therapy is also a good option for the treatment of ADA-SCID. Using gene therapy, the gene of adenosine deaminase deficiency is replaced with normal genes. This would stimulate the immune system and improve the condition of the patient. However, the success rate of gene therapy is very low. In order to prevent the patient from infections, the patient must be kept in a sterile environment. However, there is no appropriate treatment for ADA-SCID that can cure this disease.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 5

Chapter 17, Problem 1CS

Summary Introduction

To determine: The treatment options for adenosine deaminase (ADA)-deficient severe combined immunodeficiency disease (SCID).

Introduction: Mr. and Mrs. J were referred to a clinical geneticist because their 6-month-old daughter was not growing appropriately. After the examination, the doctor observed that their daughter had a constant cough, wheeze, and extensive yeast infection. The doctor also took a blood test and determined that their daughter has suffered from SCID. It was also found that their daughter had inherited mutant allele for SCID from the parents.

Expert Solution & Answer

Explanation of Solution

According to the case study, both the parents have the heterozygous mutant allele for ADA deficiency. The daughter has received both the mutant alleles from both father and mother and has become homozygous for the condition. ADA-deficient SCID is an immunodeficiency disorder. This condition causes a reduction in the synthesis of immune cells. In the absence of immune cells, the person would become immunocompromised. A person with ADA-SCID would become susceptible to infections. The possible treatment of this disease can be done by medicating the person with immune-modulating drugs.

Gene therapy is also a good option for the treatment of ADA-SCID. Using gene therapy, the gene of adenosine deaminase deficiency is replaced with normal genes. This would stimulate the immune system and improve the condition of the patient. However, the success rate of gene therapy is very low. In order to prevent the patient from infections, the patient must be kept in a sterile environment. However, there is no appropriate treatment for ADA-SCID that can cure this disease.

Answer 6

Chapter 17, Problem 1CS

Summary Introduction

To determine: The treatment options for adenosine deaminase (ADA)-deficient severe combined immunodeficiency disease (SCID).

Introduction: Mr. and Mrs. J were referred to a clinical geneticist because their 6-month-old daughter was not growing appropriately. After the examination, the doctor observed that their daughter had a constant cough, wheeze, and extensive yeast infection. The doctor also took a blood test and determined that their daughter has suffered from SCID. It was also found that their daughter had inherited mutant allele for SCID from the parents.

Expert Solution & Answer

Explanation of Solution

According to the case study, both the parents have the heterozygous mutant allele for ADA deficiency. The daughter has received both the mutant alleles from both father and mother and has become homozygous for the condition. ADA-deficient SCID is an immunodeficiency disorder. This condition causes a reduction in the synthesis of immune cells. In the absence of immune cells, the person would become immunocompromised. A person with ADA-SCID would become susceptible to infections. The possible treatment of this disease can be done by medicating the person with immune-modulating drugs.

Gene therapy is also a good option for the treatment of ADA-SCID. Using gene therapy, the gene of adenosine deaminase deficiency is replaced with normal genes. This would stimulate the immune system and improve the condition of the patient. However, the success rate of gene therapy is very low. In order to prevent the patient from infections, the patient must be kept in a sterile environment. However, there is no appropriate treatment for ADA-SCID that can cure this disease.

Answer 7

Chapter 17, Problem 1CS

Summary Introduction

To determine: The treatment options for adenosine deaminase (ADA)-deficient severe combined immunodeficiency disease (SCID).

Introduction: Mr. and Mrs. J were referred to a clinical geneticist because their 6-month-old daughter was not growing appropriately. After the examination, the doctor observed that their daughter had a constant cough, wheeze, and extensive yeast infection. The doctor also took a blood test and determined that their daughter has suffered from SCID. It was also found that their daughter had inherited mutant allele for SCID from the parents.

Answer 8

Expert Solution & Answer

Explanation of Solution

According to the case study, both the parents have the heterozygous mutant allele for ADA deficiency. The daughter has received both the mutant alleles from both father and mother and has become homozygous for the condition. ADA-deficient SCID is an immunodeficiency disorder. This condition causes a reduction in the synthesis of immune cells. In the absence of immune cells, the person would become immunocompromised. A person with ADA-SCID would become susceptible to infections. The possible treatment of this disease can be done by medicating the person with immune-modulating drugs.

Gene therapy is also a good option for the treatment of ADA-SCID. Using gene therapy, the gene of adenosine deaminase deficiency is replaced with normal genes. This would stimulate the immune system and improve the condition of the patient. However, the success rate of gene therapy is very low. In order to prevent the patient from infections, the patient must be kept in a sterile environment. However, there is no appropriate treatment for ADA-SCID that can cure this disease.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Ch. 17.8 - One treatment for peanut allergies is to give an...Ch. 17.8 - Prob. 2EG Ch. 17 - Prob. 1CS Ch. 17 - The Joneses were referred to a clinical geneticist...Ch. 17 - The Inflammatory Response Is a General a. What...Ch. 17 - The Complement System Kills Microorganisms The...Ch. 17 - The Adaptive Immune Response Is a Specific Defense...Ch. 17 - Prob. 4QP Ch. 17 - The Adaptive Immune Response Is a Specific Defense...Ch. 17 - Prob. 6QP

Concept explainers

Videos

Explanation of Solution

Want to see more full solutions like this?

Chapter 17 Solutions