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Chemistry In Focus

7th Edition
Tro + 1 other
Publisher: Cengage Learning,
ISBN: 9781337399692

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BuyFindarrow_forward

Chemistry In Focus

7th Edition
Tro + 1 other
Publisher: Cengage Learning,
ISBN: 9781337399692
Chapter 17, Problem 61E
Textbook Problem
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How do Prozac and Zoloft produce their antidepressant effect? What are their side effects?

Interpretation Introduction

Interpretation:

The working and side effects of Prozac and Zoloft in causing their antidepressant effects are to be discussed.

Concept Introduction:

The feeling of sadness and depression are normal human emotions. Extended or unremitting depression that interferes with normal activities can be a sign of an underlying mood disorder.

These mood disorders are often caused by biochemical imbalances in the brain that can be corrected with drugs. Clinical depression is diagnosed on the basis of some symptoms.

Clinical depression is partly caused by a deficit of certain neurotransmitters in the brain, especially serotonin. It appears that serotonin deficits induce adaptive changes that lead to the depressed state. If the serotonin levels are brought back to normal, the adaptive changes are reversed and depression is relieved.

Explanation of Solution

Prozac, also known as fluoxetine, was the first SSRI to be available in the United States. It works in the nerve cells to inhibit the re-uptake of serotonin and leads to a net increase in the serotonin levels in the brain. As the half-life of Prozac in the blood is one to four days, the anti-depressant action bills with repeated daily doses. The anti-depressant effects of Prozac take weeks to develop...

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Chapter 17 Solutions

Chemistry In Focus
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