(a)
Interpretation: The given compounds has to be prepared from methyl phenyl
Concept introduction: A crossed-claisen condensation is also a condensation reaction between a ketone and an ester. Primarily one product will form from crossed-claisen condensation when one of the ketone or easter do not have any alpha hydrogens.
If both ester and ketone have alpha hydrogens then primarily one product can form if LDA is used to remove alpha hydrogen to form the enolate ion. The other compound is added slowly to the enolate ion.
(b)
Interpretation: The given compounds has to be prepared from methyl phenyl ketone.
Concept introduction: A crossed-claisen condensation is also a condensation reaction between a ketone and an ester. Primarily one product will form from crossed-claisen condensation when one of the ketone or easter do not have any alpha hydrogens.
If both ester and ketone have alpha hydrogens then primarily one product can form if LDA is used to remove alpha hydrogen to form the enolate ion. The other compound is added slowly to the enolate ion.
(c)
Interpretation: The given compounds has to be prepared from methyl phenyl ketone.
Concept introduction: A crossed-claisen condensation is also a condensation reaction between a ketone and an ester. Primarily one product will form from crossed-claisen condensation when one of the ketone or easter do not have any alpha hydrogens.
If both ester and ketone have alpha hydrogens then primarily one product can form if LDA is used to remove alpha hydrogen to form the enolate ion. The other compound is added slowly to the enolate ion.
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Organic Chemistry (8th Edition)
- How can the following compounds be prepared from a carbonyl compound that has one less carbon than the desired product?arrow_forwardShow how the following compounds can be prepared from benzene:arrow_forwardShow how the following compounds can be synthesized. The only carbon-containing compounds available to you for each synthesis are shown.arrow_forward
- Show how the following compounds can be synthesized from benzenearrow_forwardPropose a synthesis for each ketone, using as one step in the sequence a Claisen condensation and the reaction sequence illustratedarrow_forwardExplain how the electrophilic substitution sequences for synthesizing the following compounds from phenol.arrow_forward
- EBK A SMALL SCALE APPROACH TO ORGANIC LChemistryISBN:9781305446021Author:LampmanPublisher:CENGAGE LEARNING - CONSIGNMENT