Biology
Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 17.5, Problem 1CS
Summary Introduction

To create: A pair of models that depict the key difference between the forms of glycosyltransferase encoded by the IA and IB alleles.

Introduction: Blood type is determined by a gene that has three different alleles. This gene codes for an enzyme called glycosyltransferase, this enzyme is useful for the synthesis of a specific polysaccharide on the surface of red blood cells.

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Task #1 Mc1r alleles: In Florida Gulf coast mice, there are two different alleles of the Melanocortin Receptor (Mcr1) gene. The sequence for both alleles is shown below. This is an internal segment of the coding (non-template) sequence of the Mcr1 gene. The reading frame is set and you do not need to find an AUG. M allele 5’...ATC ACC AAA AAC CGC AAC CTG CAC TCG... m allele 5’...ATC ACC AAA AAC TGC AAC CTG CAC TCG... A. Compare these two allele sequences and circle the nucleotides that are different. B. Do you think this change will cause a shift in the codon reading frame? Why or why not? C. Do you think that this change will cause an early stop in translation? Why or why not? Task #2 Flow of information: A codon table is provided above. The 5’ codon nucleotide is in the left column, and second codon nucleotide is on top. The Mcr1 M and m allele sequences are shown again in the central dogma grids below with the reading frame designated. Fill in the grids. In the second column…
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