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Animal Models: The Search for Behavior Genes You are a researcher studying an autosomal dominant neurodegenerative disorder. You have cloned the gene underlying the disorder and have found that it encodes an enzyme that is overexpressed in the neurons of individuals who have the disorder. To better understand how this enzyme causes neurodegeneration in humans, you make a strain of transgenic Drosophila whose nerve cells overexpress the enzyme. a. How might you use these transgenic flies to try to gain insight into the disease or identify drugs that might be useful in the treatment of the disease? b. Can you think of any potential limitations of this approach?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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Section
BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 18, Problem 12QP
Textbook Problem
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Animal Models: The Search for Behavior Genes

You are a researcher studying an autosomal dominant neurodegenerative disorder. You have cloned the gene underlying the disorder and have found that it encodes an enzyme that is overexpressed in the neurons of individuals who have the disorder. To better understand how this enzyme causes neurodegeneration in humans, you make a strain of transgenic Drosophila whose nerve cells overexpress the enzyme.

  1. a.               How might you use these transgenic flies to try to gain insight into the disease or identify drugs that might be useful in the treatment of the disease?
  2. b.              Can you think of any potential limitations of this approach?

Summary Introduction

To determine: The ways by which transgenic flies are used to identify the drug or disease that might be helpful in the treatment of diseases.

Introduction: To generate a treatment for human diseases animal model systems are used. The mouse is a primary animal which is used as a model to study human behavioral disorders. There is about 90% of genetic similarity found between mice and humans.

Explanation of Solution

The transgenic flies were used as an animal model for understanding the pattern of a disease. Those genes which cause disorders in humans and are responsible for the malfunctioning of the human system ...

Summary Introduction

To determine: The potential limitation of this approach.

Introduction: To generate a treatment for human diseases animal model systems are used. The mouse is a primary animal which is used as a model to study human behavioral disorders. There is about 90% of genetic similarity found between mice and humans.

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