Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 18, Problem 20P
Understanding the Mechanism of Hemolytic Anemia Genetic defects in glycolytic enzymes can have serious consequences for humans For example, defects in the gene for pyruvate kinase can result in a condition known as hemolytic anemia. Consult a reference to learn about hemolytic anemia, and discuss why such genetic defects lead to this condition.
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Chapter 18 Solutions
Biochemistry
Ch. 18 - Characterizing Glycolysis List the reactions of...Ch. 18 - Radiotracer Labeling of Pyruvate from Glucose...Ch. 18 - Effects of Changing Metabolite Concentrations on...Ch. 18 - Prob. 4PCh. 18 - Prob. 5PCh. 18 - The Reactions and Meehanisms of the Leloir Pathway...Ch. 18 - The Effect of lodoacetic Acid on the...Ch. 18 - Prob. 8PCh. 18 - Comparing Glycolysis Entry Points for Sucrose...Ch. 18 - Prob. 10P
Ch. 18 - Prob. 11PCh. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Energetic of Fructose-1 ,6-bis P Hydrolysis...Ch. 18 - Prob. 15PCh. 18 - Energetics of the Hexokinase Reaction The...Ch. 18 - Prob. 17PCh. 18 - Distinguishing the Mechanisms of Class I and Class...Ch. 18 - Prob. 19PCh. 18 - Understanding the Mechanism of Hemolytic Anemia...Ch. 18 - Prob. 21PCh. 18 - Based on your residing of this chapter, what would...Ch. 18 - Examine the ActiveModel for alcohol dehydrogenase...Ch. 18 - Based on your knowledge of the structure of NAD+...Ch. 18 - Using the ActiveModel for phosphofructokinase...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Effects of Changing Metabolite Concentrations on Glycolysis In an erythrocyte undergoing glycolysis what would be the effect of a sudden increase in the concentration of a. AΤP? b. AMP? c. fructose-1.6-bisphosphate? d. fructose-2, 6-bisphosphate? e. citrate? f. glucose-6-phospthate?arrow_forwardComplete oxidation of a 16-carbon fatty acid can yield 129 molecules of ATP Study Figure 19.2 and determine how many ATP molecules would be generated if a 16-carbon fatly acid were metabolized solely by the TCA cycle, in the form of S acetyl-CoA molecules.arrow_forwardCharacterizing Glycolysis List the reactions of glycolysis that a. are energy consuming (under standard-stale conditions), b. are energy yielding (under standard-state conditions), c. consume ATP. d. yield ATP e. are strongly influenced by changes in concentration of substrate and product because of their molecularity. f. are at or near equilibrium in the erythrocyte (see Table 18.2).arrow_forward
- Cancer cells have a high amount of hexokinase. Explain why.arrow_forwardDescribe the two models that explain the binding of allosteric enzymes. Use either model to explain the binding ofoxygen to hemoglobin.arrow_forwardTPI deficiency is a rare human condition. Patients who lack TPI cannot convert the triose dihydroxyacetone phosphate into glyceraldehyde 3-phosphate.What happens to glycolysis in TPI patients?TPI patients suffer from chronic hemolytic anemia (abnormal breakdown of red blood cells) and have variable neuromuscular dysfunctions, including muscle weakness, poor muscle tone, and atrophy. Most die of respiratory failure during childhood. Explain why TPI-deficient patients exhibit these conditions using the diagram to justify your answer. TPI is enzyme 5.G6PD deficiency is one of the most common human genetic conditions, affecting about 40 million people worldwide. Patients suffer from hemolytic anemia when exposed to certain drugs, viral or bacterial disease, or fava beans.arrow_forward
- Some animals have higher concentrations of mitochondria in their muscle cells. Explain the metabolic advantages.arrow_forwardConsumption of nitrate-rich vegetables such as spinach have been shown to reduce blood pressure in prehypertensive individuals (i.e., those having no history of clinical hypertension), a phenomenon attributed to increased nitric oxide synthesis. Describe the reactions that convert nitrate (NO3 −) to nitric oxide (NO•) in the body.arrow_forwardThe removal of fatty acids from triacylglycerols leaves glycerol. Show how the actions of glycerol kinase and glycerol-3-phosphate dehydrogenase on glycerol produce an intermediate of glycolysis.arrow_forward
- Tumor cells, which tend to grow rapidly, typically express high levels of the glycolytic enzymes. Explain the advantage of high glycolytic flux for these cells.arrow_forwardIn the liver, fructose can be converted into glyceraldehyde 3- phosphate and dihydroxyacetone phosphate without passing through the phosphofructokinase-regulated reaction. Show the reactions that make this conversion possible. Why might ingesting high levels of fructose have deleterious physiological effects?arrow_forwardPhosphoglucokinase catalyzes the phosphorylation of the C6-OH group of G1P. Why is this enzyme important for the normal function of phosphoglucomutase?arrow_forward
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