Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 18, Problem 3P
Effects of Changing Metabolite Concentrations on Glycolysis In an erythrocyte undergoing glycolysis what would be the effect of a sudden increase in the concentration of
a. AΤP?
b. AMP?
c. fructose-1.6-bisphosphate?
d. fructose-2, 6-bisphosphate?
e. citrate?
f. glucose-6-phospthate?
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Glucosamine is a common compound that inhibits hexokinase action (the transfer of a phosphate group to glucose during glycolysis).
A) Describe the consequences of glucosamine exposure on cellular respiration.
B) Is glucosamine exposure fatal? Why or why not?
The hypoxia-inducible factor (HIF) plays an important role in cellular respiration in response to low O2 levels.
Using molecular biology, it’s possible to generate animal cells that lack HIF. What would occur if these cells were placed in a low O2 environment?
A.
Inhibition of pyruvate decarboxylase complex activity.
B.
Increase rate of respiratory electron transport.
C.
Build-up of acetyl-CoA in mitochondria.
D.
Build-up of ATP within mitochondria.
Discuss the relationship between redox potentials E0’ and the organization of the components of the electron transport chain. Be specific, i.e., use data/actual values to back up your discussion.
a) What are the values of E0’ for all the components of the ETS?
b)How are the E0’ related to ∆G values?
c) How do the values of E0’ vary among the participants in the ETS relative to their position in the ETS?
Chapter 18 Solutions
Biochemistry
Ch. 18 - Characterizing Glycolysis List the reactions of...Ch. 18 - Radiotracer Labeling of Pyruvate from Glucose...Ch. 18 - Effects of Changing Metabolite Concentrations on...Ch. 18 - Prob. 4PCh. 18 - Prob. 5PCh. 18 - The Reactions and Meehanisms of the Leloir Pathway...Ch. 18 - The Effect of lodoacetic Acid on the...Ch. 18 - Prob. 8PCh. 18 - Comparing Glycolysis Entry Points for Sucrose...Ch. 18 - Prob. 10P
Ch. 18 - Prob. 11PCh. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Energetic of Fructose-1 ,6-bis P Hydrolysis...Ch. 18 - Prob. 15PCh. 18 - Energetics of the Hexokinase Reaction The...Ch. 18 - Prob. 17PCh. 18 - Distinguishing the Mechanisms of Class I and Class...Ch. 18 - Prob. 19PCh. 18 - Understanding the Mechanism of Hemolytic Anemia...Ch. 18 - Prob. 21PCh. 18 - Based on your residing of this chapter, what would...Ch. 18 - Examine the ActiveModel for alcohol dehydrogenase...Ch. 18 - Based on your knowledge of the structure of NAD+...Ch. 18 - Using the ActiveModel for phosphofructokinase...
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