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Cisplatin [ cis -diamminedichloroplatinum(II)] is a potent treatment for certain types of cancers, but the trans isomer is not effective. What is the equilibrium constant at 298 K for the transformation of the cis to the trans isomer? Which is the favored isomer at 298 K, the cis or the trans isomer?

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Chemistry & Chemical Reactivity

9th Edition
John C. Kotz + 3 others
Publisher: Cengage Learning
ISBN: 9781133949640

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Chapter
Section
BuyFindarrow_forward

Chemistry & Chemical Reactivity

9th Edition
John C. Kotz + 3 others
Publisher: Cengage Learning
ISBN: 9781133949640
Chapter 18, Problem 66IL
Textbook Problem
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Cisplatin [cis-diamminedichloroplatinum(II)] is a potent treatment for certain types of cancers, but the trans isomer is not effective. What is the equilibrium constant at 298 K for the transformation of the cis to the trans isomer? Which is the favored isomer at 298 K, the cis or the trans isomer?

Chapter 18, Problem 66IL, Cisplatin [cis-diamminedichloroplatinum(II)] is a potent treatment for certain types of cancers, but

Interpretation Introduction

Interpretation:

The equilibrium constant for the transformation of cisplatin to transplatin at 298 K should be calculated.

Concept introduction:

The Gibbs free energy or the free energy change is a thermodynamic quantity represented by ΔrGo. It can be calculated in a similar manner as entropy and enthalpy. The expression for the free energy change is:

  ΔrG°fG°(products)fG°(reactants)

It is related to entropy and entropy by the following expression,

  ΔrGorHo-TΔrSo

Here, ΔrH° is the change in enthalpy and ΔrS° is the change in entropy.

ΔrGo is related to the equilibrium constant Kp by the equation,

  ΔrGo= -RTlnKp

The rearranged expression is,

  Kp= eΔrGoRT

Explanation of Solution

The equilibrium constant for the transformation of cisplatin to transplatin at 298 K is calculated below.

Given:

The given reaction is,

  CisplatinTransplatin

The ΔrGo for cisplatin is 228.7 kJ/mol.

The ΔrGo for transplatin is 222.8 kJ/mol.

  ΔrG°fG°(products)fG°(reactants)=[(1 mol Transplatin/mol-rxn)ΔfG°[

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Chapter 18 Solutions

Chemistry & Chemical Reactivity
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Ch. 18.4 - Without looking up their standard entropies in...Ch. 18.4 - Without doing any calculations, predict the sign...Ch. 18.4 - Calculate rS for the following reaction at 25 C....Ch. 18.5 - Based on rH and rS, predict the spontaneity of the...Ch. 18.5 - Calculate rS for the following reaction at 25 C...Ch. 18.5 - Calculate S(universe) for the following reaction...Ch. 18.5 - 3. If rH° = +467.9 kJ/mol-rxn and rS° = +560.7 J/K...Ch. 18.6 - For a reaction to be spontaneous, rG will be...Ch. 18.6 - A reaction for which rG 0 is (a) product-favored...Ch. 18.7 - Using values of fH and S to find rH and rS,...Ch. 18.7 - Calculate the standard free energy change for the...Ch. 18.7 - Oxygen was first prepared by Joseph Priestley...Ch. 18.7 - Determine the value of rG for the reaction C(s) +...Ch. 18.7 - Determine the value of the equilibrium constant,...Ch. 18.7 - Nitrogen and oxygen can react to form nitrogen...Ch. 18.7 - 1. Given that H° = −2219 kJ/mol-rxn and that rS° =...Ch. 18.7 - 2. Using values of rG°, determine the value of rG°...Ch. 18.7 - 3. The value of Kp for the following reaction at...Ch. 18.7 - Consider the hydrolysis reactions of creatine...Ch. 18.7 - Assume the reaction A(aq) + B(aq) C(aq) +...Ch. 18.A - The decomposition of diamond to graphite...Ch. 18.A - It has been demonstrated that buckminsterfullerene...Ch. 18 - Which substance has the higher entropy? (a) dry...Ch. 18 - Which substance has the higher entropy? 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Using values of fG, calculate rG for each of the...Ch. 18 - For the reaction BaCO3(s) BaO(s) + CO2(g), rG =...Ch. 18 - For the reaction TiCl2(s) + Cl2(g) TiCl4(), rG =...Ch. 18 - Determine whether the reactions listed below are...Ch. 18 - Determine whether the reactions listed below are...Ch. 18 - Heating some metal carbonates, among them...Ch. 18 - Calculate rH and rS for the reaction of tin(IV)...Ch. 18 - The standard free energy change, rG, for the...Ch. 18 - The standard free energy change, rG, for the...Ch. 18 - Calculate rG at 25 C for the formation of 1.00 mol...Ch. 18 - Calculate rG at 25 C for the formation of 1.00 mol...Ch. 18 - For the synthesis of ammonia from its elements at...Ch. 18 - For the decomposition of solid calcium carbonate...Ch. 18 - Compare the compounds in each set below and decide...Ch. 18 - Using standard entropy values, calculate rS for...Ch. 18 - About 5 billion kilograms of benzene, C6H6, are...Ch. 18 - Hydrogenation, the addition of hydrogen to an...Ch. 18 - Is the combustion of ethane, C2H6, product-favored...Ch. 18 - Write a balanced equation that depicts the...Ch. 18 - When vapors from hydrochloric acid and aqueous...Ch. 18 - Calculate S(system), S(surroundings), and...Ch. 18 - Methanol is now widely used as a fuel in race...Ch. 18 - The enthalpy of vaporization of liquid diethyl...Ch. 18 - Calculate the entropy change, rS, for the...Ch. 18 - Using thermodynamic data, estimate the normal...Ch. 18 - The following reaction is reactant-favored at...Ch. 18 - When calcium carbonate is heated strongly, CO2 gas...Ch. 18 - Sodium reacts violently with water according to...Ch. 18 - Yeast can produce ethanol by the fermentation of...Ch. 18 - Elemental boron, in the form of thin fibers, can...Ch. 18 - Estimate the vapor pressure of ethanol at 37 C...Ch. 18 - The equilibrium constant, Kp, for N2O4(g) 2...Ch. 18 - Estimate the boiling point of water in Denver,...Ch. 18 - The equilibrium constant for the butane ...Ch. 18 - A crucial reaction for the production of synthetic...Ch. 18 - 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