The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene. Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

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Chapter 19, Problem 18QP

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To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

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Please help with all of these! thank you so much! Neutral regions of a species’ genome that are distant from any selected sites have apairwise diversity (?) of 0.01. Other regions of the genome have reduced genetic variation,and selective sweeps could be responsible for the reduction. Assume that selective sweepshappen at a rate of 10^-10 per bp, and they take 500 generations to reach fixation. Therecombination rate in regions where selective sweeps might occur is 10^-8 per bp. Theeffective population size of the species is 10^5. A. Find the expected genetic diversity (? per bp) in regions where selective sweepsmight be occurring.B. Find the deleterious mutation rate (per bp) that would be required to produce anequivalent reduction in genetic diversity as a result of background selection (BGS)?Assume the same recombination rate as above.

Recall from our classes on molecular evolution that some proteins evolve more rapidly than others. For example, the oxygen-carrying protein myoglobin evolves more quickly than the D1 protein of photosystem II. What explains this difference in the rate of protein evolution? A. Proteins like myoglobin have evolved more recently than proteins like D1 and thus have been forced to evolve more quickly. B. Changes to the sequence of some proteins can be tolerated as they don’t alter fitness; for other proteins, sequence changes are usually harmful. C. In constrained proteins like D1, evolution results primarily from nucleotide changes that alter the amino acid sequence of the protein. D. Protein evolution is dependent upon the rate of gene mutation and some genes have a higher rate of mutation than others.

n class we investigated the reason cystic fibrosis is maintained in the human population in higher frequency than we expected given the deleterious effects of being homozygous at the CFTR gene. We calculated the actual mutation rate of the CFTR gene to be 6.7 x 10-7. The mutation rate expected under mutation-selection balance was 4 x 10-4. What is the most plausible explanation as to why cystic fibrosis is maintained in the human population at a higher frequency than we expect? a. Negative selection against the CFTR deleterious alleles is too weak to eliminate the alleles from the human population. b. Positive selection for the CFTR deleterious alleles is likely occurring in response to some other selective pressure in the human population, possibly resistance to typhoid fever. c. The CFTR gene has an exceedingly low mutation rate causing humans to have no genetic variation at that gene. d. The CFTR gene has an exceedingly high mutation rate and that is…

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Chapter 19, Problem 18QP

Summary Introduction

To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

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Chapter 19, Problem 18QP

Summary Introduction

To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

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Chapter 19, Problem 18QP

Summary Introduction

To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

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Chapter 19, Problem 18QP

Summary Introduction

To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

Answer 6

Chapter 19, Problem 18QP

Summary Introduction

To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

Answer 7

Chapter 19, Problem 18QP

Summary Introduction

To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

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Ch. 19.8 - Why dont genetic markers on the Y chromosome...Ch. 19.8 - Prob. 2GR Ch. 19 - If you suspected that heterozygous carriers of a...Ch. 19 - If allele frequencies in the hemoglobin gene are...Ch. 19 - Prob. 1QP Ch. 19 - How Can We Measure Allele Frequencies in...Ch. 19 - How Can We Measure Allele Frequencies in...Ch. 19 - Prob. 4QP Ch. 19 - Prob. 5QP Ch. 19 - How Can We Measure Allele Frequencies in...

The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene. Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

Solution Summary: The author explains the founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene. The founder effect causes a shift in allele frequency due to the establishment of new population.

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To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

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Chapter 19 Solutions

The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene. Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

Solution Summary: The author explains the founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene. The founder effect causes a shift in allele frequency due to the establishment of new population.

Concept explainers

Videos

To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene. Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

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Chapter 19 Solutions

To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.