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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
ISBN: 9781305251052
Textbook Problem

Measuring Genetic Diversity in Human Populations

A specific mutation in the BRCA1 gene has been estimated to be present in approximately 1% of Ashkenazi Jewish women of Eastern European descent. This specific alteration, 185delAG, is found about three times more often in this ethnic group than the combined frequency of the other 125 mutations found to date. It is believed that the mutation is the result of a founder effect from many centuries ago. Explain the founder principle.

Summary Introduction

To determine: The founder principle in case of Ashkenazi Jewish Women infected by BRCA1 gene.

Introduction: The concept of founder effect was initially given by Ernst Mayr in the year 1942. The BRCA1 gene is a gene that is responsible for causing breast cancer in women.

Explanation

The founder effect can be explained as the formation of a new small population that emerges out of a larger population. The founder effect causes a shift in the frequency of alleles due to the establishment of new population. The allele frequency of the newly established population denotes the allele frequency of that entire population...

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