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Antibiotic Effects on Mitochondria Tetracyclines are antibiotics that inactivate bacterial ribosomes. Knowing that mitochondria evolved from bacteria, researchers suspected tetracyclines might affect mitochondria by harming their ribosomes. FIGURE 19. 11 shows the effects of an experiment in which mice were given either tetracycline or a control antibiotic that affects cell wall production. After 10 days of treatment, the function of mitochondria in the mice was assessed. FIGURE 19.11 Effects of tetracycline on mitochondria . Mice received low-dose tetracycline, high-dose tetracycline, or a control antibiotic that targets bacterial cell walls. Mitochondrial function was assessed by looking at oxygen consumption rate and ATP content in homogenized mouse livers. Bar graphs show means with standard error. An * indicates a statistically significant difference between the experimental and the control treatments. Do these results support the hypothesis that tetracyclines impair mitochondrial function?

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Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332

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Chapter
Section
BuyFindarrow_forward

Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
Publisher: Cengage Learning
ISBN: 9781337408332
Chapter 19, Problem 4DAA
Textbook Problem
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Antibiotic Effects on Mitochondria Tetracyclines are antibiotics that inactivate bacterial ribosomes. Knowing that mitochondria evolved from bacteria, researchers suspected tetracyclines might affect mitochondria by harming their ribosomes. FIGURE 19. 11 shows the effects of an experiment in which mice were given either tetracycline or a control antibiotic that affects cell wall production. After 10 days of treatment, the function of mitochondria in the mice was assessed.

Chapter 19, Problem 4DAA, Antibiotic Effects on Mitochondria Tetracyclines are antibiotics that inactivate bacterial

FIGURE 19.11 Effects of tetracycline on mitochondria. Mice received low-dose tetracycline, high-dose tetracycline, or a control antibiotic that targets bacterial cell walls. Mitochondrial function was assessed by looking at oxygen consumption rate and ATP content in homogenized mouse livers. Bar graphs show means with standard error. An * indicates a statistically significant difference between the experimental and the control treatments.

Do these results support the hypothesis that tetracyclines impair mitochondrial function?

Summary Introduction

To determine: Whether the results from this study support the hypothesis that tetracycline impairs mitochondrial function.

Concept introduction: Mitochondria are the powerhouse of the cell. It requires oxygen to produce the ATP in adequate quantities to perform the energy-utilising reactions in the eukaryotic organisms. Tetracycline is an antibiotic that works only against bacterial infections and does not work against viral infections.

Explanation of Solution

The study indicates that the tetracycline antibiotic has the ability to impair the mitochondrial functions. The mice administered with the control antibiotic shows high in oxygen consumption rate and ATP content...

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