Understanding Pathophysiology, 6e
Understanding Pathophysiology, 6e
6th Edition
ISBN: 9780323354097
Author: Sue E. Huether RN PhD, Kathryn L. McCance RN PhD
Publisher: Elsevier Science
Question
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Chapter 19.1, Problem 1QC
Summary Introduction

To explain: The mechanism of receptor-associated hormonal disorder.

Concept introduction: Hormones are the chemical messenger, which is secreted by the endocrine system. The target cells may sometimes fail to respond to hormones because of the cell surface receptor-associated disorders, circulating inhibitors, and intracellular disorders.

Expert Solution & Answer
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Explanation of Solution

The cell surface receptor-associated disorders are mostly observed in water-soluble hormones like insulin.

The mechanism of receptor-associated hormonal disorder includes as follows:

  • Reduction in the receptors number leads to cause a decrease or abnormal hormone-receptor binding.
  • Impairment of receptor function results in hormonal insensitivity.
  • Presence of antibodies against specific receptors may either imitate hormonal action or decrease the existing binding sites.
  • Abnormal expression of receptor functions (as it takes place in certain tumor cells).

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