Synthesis of glycogen particle is done by Tyr 1 9 4 of glycogenin which reacts with glucose unit and produce tyrosyl glucose. UDP-glucose produces glucose unit. This complete reaction is catalyzing by the glycogenin. Working mechanism of this reaction is to be explained. Concept introduction: Complete mechanism is described by nucleophilic attack of aspartate which is residue of catalyst glycogenin.

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Properties of an Enzyme of Prostaglandin Synthesis.Prostaglandins are a class of eicosanoids, fatty acid derivatives with a variety of extremely potent actions on vertebrate tissues. They are re-sponsible for producing fever and inflammation and its associated pain. Prostaglandins are derived from the 20-carbon fatty acid arachidonic acid in a reaction catalyzed by the enzyme prostaglandin en-doperoxide synthase. This enzyme, a cyclooxygenase, uses oxygen to convert arachidonic acid to PGG2, the immediate precursor of many different prostaglandins (prostaglandin synthesis is described in Chapter 21). a)The kinetic data given below are for the reaction catalyzed by prostaglandin endoperoxide synthase. Focusing here on the first two columns, determine the Vmax and Km of the enzyme. b)Ibuprofen is an inhibitor of prostaglandin endoperoxide synthase. By inhibiting the synthesis of prostaglandins, ibuprofen reduces inflammation and pain. Using the data in the first and third columns of…

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Question

Chapter 22, Problem 19P

Interpretation Introduction

Interpretation:

Synthesis of glycogen particle is done by Tyr¹⁹⁴of glycogenin which reacts with glucose unit and produce tyrosyl glucose. UDP-glucose produces glucose unit. This complete reaction is catalyzing by the glycogenin. Working mechanism of this reaction is to be explained.

Concept introduction:

Complete mechanism is described by nucleophilic attack of aspartate which is residue of catalyst glycogenin.

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Properties of an Enzyme of Prostaglandin Synthesis.Prostaglandins are a class of eicosanoids, fatty acid derivatives with a variety of extremely potent actions on vertebrate tissues. They are re-sponsible for producing fever and inflammation and its associated pain. Prostaglandins are derived from the 20-carbon fatty acid arachidonic acid in a reaction catalyzed by the enzyme prostaglandin en-doperoxide synthase. This enzyme, a cyclooxygenase, uses oxygen to convert arachidonic acid to PGG2, the immediate precursor of many different prostaglandins (prostaglandin synthesis is described in Chapter 21). a)The kinetic data given below are for the reaction catalyzed by prostaglandin endoperoxide synthase. Focusing here on the first two columns, determine the Vmax and Km of the enzyme. b)Ibuprofen is an inhibitor of prostaglandin endoperoxide synthase. By inhibiting the synthesis of prostaglandins, ibuprofen reduces inflammation and pain. Using the data in the first and third columns of…

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