In order to vaccinate people against diseases by having them eat antigens (such as the cholera toxin) or antibodies expressed in an edible vaccine, the antigen must reach the cells of the small intestine in order to enter the bloodstream. What are some potential problems of this method?

Question

Want to see more full solutions like this?

Answer 1

Textbook Question

Chapter 22, Problem 1NST

In order to vaccinate people against diseases by having them eat antigens (such as the cholera toxin) or antibodies expressed in an edible vaccine, the antigen must reach the cells of the small intestine in order to enter the bloodstream. What are some potential problems of this method?

Expert Solution & Answer

Summary Introduction

To determine: The potential problems associated with the oral vaccine.

Introduction: Vaccination is the process of immunizing a person against disease by administrating weak or dead microbes that cause the disease so that immune system recognizes these microbes and develop immune cells against the disease for future encounters.

Explanation of Solution

For vaccines to form immune cells, it is necessary that the vaccine comes in contact with the blood. In the case of oral administration of the vaccines, the vaccines can only enter the bloodstream during the absorption stage in the small intestine. So, the potential problems associated with oral administration of vaccines are as follows:

The molecular integration of the microbes present in the vaccine should be able to tolerate the harsh condition of the gastrointestinal (GI) tract.
Oral vaccines also require to be administered in larger quantity because, in some people, induction of tolerance is difficult at a lower concentration.
Larger concentration increases the chances of a person receiving the disease instead of immunization.

Conclusion

Oral vaccines should be able to tolerate the harsh conditions of the GI tract, and the concentration of the vaccine should also be high which increases the chances of a person being infected by the disease due to the vaccine.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Students have asked these similar questions

hypothetically speaking, if a rapid test was being made to detect RSV (RSV antigen), the conjugate pad would contain the anti-RSV antibody conjugated with HRP. The test line would be the anti-RSV antibody. What would be a suitable control antibody to use?

You want to product human immunoglobulin G using a recombinant Escherichia coli system. Design the whole procedure and strategy by yourself.

To understand the genes responsible for growth and infectivity in a disease-causing bacterial strain, you perform chemical mutagenesis on a culture of these bacteria. In the course of your investigation into the properties of the resulting mutants, you identify a set of mutant bacteria that is still viable but their virulence is significantly impaired. How might these mutants be useful for vaccine development?

Answer 2

Textbook Question

Chapter 22, Problem 1NST

In order to vaccinate people against diseases by having them eat antigens (such as the cholera toxin) or antibodies expressed in an edible vaccine, the antigen must reach the cells of the small intestine in order to enter the bloodstream. What are some potential problems of this method?

Expert Solution & Answer

Summary Introduction

To determine: The potential problems associated with the oral vaccine.

Introduction: Vaccination is the process of immunizing a person against disease by administrating weak or dead microbes that cause the disease so that immune system recognizes these microbes and develop immune cells against the disease for future encounters.

Explanation of Solution

For vaccines to form immune cells, it is necessary that the vaccine comes in contact with the blood. In the case of oral administration of the vaccines, the vaccines can only enter the bloodstream during the absorption stage in the small intestine. So, the potential problems associated with oral administration of vaccines are as follows:

The molecular integration of the microbes present in the vaccine should be able to tolerate the harsh condition of the gastrointestinal (GI) tract.
Oral vaccines also require to be administered in larger quantity because, in some people, induction of tolerance is difficult at a lower concentration.
Larger concentration increases the chances of a person receiving the disease instead of immunization.

Conclusion

Oral vaccines should be able to tolerate the harsh conditions of the GI tract, and the concentration of the vaccine should also be high which increases the chances of a person being infected by the disease due to the vaccine.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 3

Textbook Question

Chapter 22, Problem 1NST

In order to vaccinate people against diseases by having them eat antigens (such as the cholera toxin) or antibodies expressed in an edible vaccine, the antigen must reach the cells of the small intestine in order to enter the bloodstream. What are some potential problems of this method?

Expert Solution & Answer

Summary Introduction

To determine: The potential problems associated with the oral vaccine.

Introduction: Vaccination is the process of immunizing a person against disease by administrating weak or dead microbes that cause the disease so that immune system recognizes these microbes and develop immune cells against the disease for future encounters.

Explanation of Solution

For vaccines to form immune cells, it is necessary that the vaccine comes in contact with the blood. In the case of oral administration of the vaccines, the vaccines can only enter the bloodstream during the absorption stage in the small intestine. So, the potential problems associated with oral administration of vaccines are as follows:

The molecular integration of the microbes present in the vaccine should be able to tolerate the harsh condition of the gastrointestinal (GI) tract.
Oral vaccines also require to be administered in larger quantity because, in some people, induction of tolerance is difficult at a lower concentration.
Larger concentration increases the chances of a person receiving the disease instead of immunization.

Conclusion

Oral vaccines should be able to tolerate the harsh conditions of the GI tract, and the concentration of the vaccine should also be high which increases the chances of a person being infected by the disease due to the vaccine.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 4

Textbook Question

Chapter 22, Problem 1NST

In order to vaccinate people against diseases by having them eat antigens (such as the cholera toxin) or antibodies expressed in an edible vaccine, the antigen must reach the cells of the small intestine in order to enter the bloodstream. What are some potential problems of this method?

Expert Solution & Answer

Summary Introduction

To determine: The potential problems associated with the oral vaccine.

Introduction: Vaccination is the process of immunizing a person against disease by administrating weak or dead microbes that cause the disease so that immune system recognizes these microbes and develop immune cells against the disease for future encounters.

Explanation of Solution

For vaccines to form immune cells, it is necessary that the vaccine comes in contact with the blood. In the case of oral administration of the vaccines, the vaccines can only enter the bloodstream during the absorption stage in the small intestine. So, the potential problems associated with oral administration of vaccines are as follows:

The molecular integration of the microbes present in the vaccine should be able to tolerate the harsh condition of the gastrointestinal (GI) tract.
Oral vaccines also require to be administered in larger quantity because, in some people, induction of tolerance is difficult at a lower concentration.
Larger concentration increases the chances of a person receiving the disease instead of immunization.

Conclusion

Oral vaccines should be able to tolerate the harsh conditions of the GI tract, and the concentration of the vaccine should also be high which increases the chances of a person being infected by the disease due to the vaccine.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 5

Textbook Question

Answer 6

Textbook Question

Answer 7

Expert Solution & Answer

Summary Introduction

To determine: The potential problems associated with the oral vaccine.

Introduction: Vaccination is the process of immunizing a person against disease by administrating weak or dead microbes that cause the disease so that immune system recognizes these microbes and develop immune cells against the disease for future encounters.

Explanation of Solution

For vaccines to form immune cells, it is necessary that the vaccine comes in contact with the blood. In the case of oral administration of the vaccines, the vaccines can only enter the bloodstream during the absorption stage in the small intestine. So, the potential problems associated with oral administration of vaccines are as follows:

The molecular integration of the microbes present in the vaccine should be able to tolerate the harsh condition of the gastrointestinal (GI) tract.
Oral vaccines also require to be administered in larger quantity because, in some people, induction of tolerance is difficult at a lower concentration.
Larger concentration increases the chances of a person receiving the disease instead of immunization.

Conclusion

Oral vaccines should be able to tolerate the harsh conditions of the GI tract, and the concentration of the vaccine should also be high which increases the chances of a person being infected by the disease due to the vaccine.

Answer 8

Expert Solution & Answer

Summary Introduction

To determine: The potential problems associated with the oral vaccine.

Introduction: Vaccination is the process of immunizing a person against disease by administrating weak or dead microbes that cause the disease so that immune system recognizes these microbes and develop immune cells against the disease for future encounters.

Explanation of Solution

For vaccines to form immune cells, it is necessary that the vaccine comes in contact with the blood. In the case of oral administration of the vaccines, the vaccines can only enter the bloodstream during the absorption stage in the small intestine. So, the potential problems associated with oral administration of vaccines are as follows:

The molecular integration of the microbes present in the vaccine should be able to tolerate the harsh condition of the gastrointestinal (GI) tract.
Oral vaccines also require to be administered in larger quantity because, in some people, induction of tolerance is difficult at a lower concentration.
Larger concentration increases the chances of a person receiving the disease instead of immunization.

Conclusion

Oral vaccines should be able to tolerate the harsh conditions of the GI tract, and the concentration of the vaccine should also be high which increases the chances of a person being infected by the disease due to the vaccine.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Summary Introduction

To determine: The potential problems associated with the oral vaccine.

Introduction: Vaccination is the process of immunizing a person against disease by administrating weak or dead microbes that cause the disease so that immune system recognizes these microbes and develop immune cells against the disease for future encounters.

Answer 12

Explanation of Solution

For vaccines to form immune cells, it is necessary that the vaccine comes in contact with the blood. In the case of oral administration of the vaccines, the vaccines can only enter the bloodstream during the absorption stage in the small intestine. So, the potential problems associated with oral administration of vaccines are as follows:

The molecular integration of the microbes present in the vaccine should be able to tolerate the harsh condition of the gastrointestinal (GI) tract.
Oral vaccines also require to be administered in larger quantity because, in some people, induction of tolerance is difficult at a lower concentration.
Larger concentration increases the chances of a person receiving the disease instead of immunization.

Answer 13

Conclusion

Oral vaccines should be able to tolerate the harsh conditions of the GI tract, and the concentration of the vaccine should also be high which increases the chances of a person being infected by the disease due to the vaccine.

Answer 14

Ch. 22 - In order to vaccinate people against diseases by...Ch. 22 - Prob. 2NST Ch. 22 - Prob. 1CS Ch. 22 - Prob. 2CS Ch. 22 - Prob. 3CS Ch. 22 - HOW DO WE KNOW? In this chapter, we focused on a...Ch. 22 - Prob. 2PDQ Ch. 22 - Why are most recombinant human proteins produced...Ch. 22 - One of the major causes of sickness, death, and...Ch. 22 - Sequencing the human genome, the development of...

In order to vaccinate people against diseases by having them eat antigens (such as the cholera toxin) or antibodies expressed in an edible vaccine, the antigen must reach the cells of the small intestine in order to enter the bloodstream. What are some potential problems of this method?

Concept explainers

Videos

Explanation of Solution

Want to see more full solutions like this?

Chapter 22 Solutions