Sotalol is a B-adrenergic blocker used to treat certain types of cardiac arrhythmias. Its hydrochloride salt is marketed under several trade names, including Betapace. Follow- ing is a retrosynthetic analysis. OH H H Me Me H. H. Sotalol (A) Br Me Me H,N H (В) (C) Aniline

Sotalol is a B-adrenergic blocker used to treat certain types of cardiac arrhythmias. Its hydrochloride salt is marketed under several trade names, including Betapace. Follow- ing is a retrosynthetic analysis. OH H H Me Me H. H. Sotalol (A) Br Me Me H,N H (В) (C) Aniline

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section: Chapter Questions

Problem 23.61P

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Question

Propose a synthesis for sotalol from aniline.

Sotalol is a B-adrenergic blocker used to treat certain types of cardiac arrhythmias. Its
hydrochloride salt is marketed under several trade names, including Betapace. Follow-
ing is a retrosynthetic analysis.
OH
H
H
Me
Me
H.
H.
Sotalol
(A)
Br
Me
Me
H,N
H
(В)
(C)
Aniline

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