Brock Biology of Microbiology - Modern MasteringBiology
Brock Biology of Microbiology - Modern MasteringBiology
15th Edition
ISBN: 9780134602325
Author: MADIGAN
Publisher: PEARSON
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Chapter 24, Problem 1AQ
Summary Introduction

To explain:

The steps which should be taken to restore normal microbiota of intestine after extended antibiotic therapy. Also, explain two ways by which exact microbiota and some representative species could also be returned.

Introduction:

Normal microbiota of intestine plays various important roles such as they prevent colonization of pathogens inside the body of an organism. They are also very important for proper digestion of complex carbohydrates for their easy breakdown. These bacteria play an important role in the immune system of the body. Prolonged treatment of antibiotics leads to the destruction and removal of normal microbiota.

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Explanation of Solution

Normal microbiota of intestine performs a variety of useful function such as they help in digestion of food particles into simple compounds. They also prevent individual’s body from harmful pathogens and maintain immune responses of the body. If a person is exposed to long term treatment of antibiotics, normal microbiota of body effects in several ways. For restoring normal microbiota probiotics can be taken. These probiotics would help in restoring gut flora following antibiotics. One week probiotics treatment should be given to the patient if he or she is on prolonged antibiotic treatment. Several doses which are sufficient for rebuilding the glycocalyx (a component of the cell wall) can be given for further restoration.

Two ways by which intestinal microbiota and some representative species could be returned are described as below:

(1) For normal microbiota, consumption of probiotics is generally advised in most cases. These probiotics would not show any side effects and can be effectively taken for restoring microbial flora.

(2) Consumption of fiber-rich food is also advised for the restoration of some representative species.

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Over the years research shows  the effect of dietary interventions (prebiotic spike-ins, meal replacement) on the gut microbiome and found some interesting (and mixed!) results.  Can the  use of dietary supplements/meal replacement strategies  used in a clinical/healthcare setting to help people with certain gut conditions? What will be some  positives and negatives to using these dietary therapies?
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