Biochemistry
Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Textbook Question
Chapter 24, Problem 1P

Explaining the Stoichiometry of Fatty Acid Synthesis Carefully count and account for each of the atoms and charges in the equations for the synthesis of palmitoyl-CoA, the synthesis of malonyl-CoA, and the overall reaction for the synthesis of palmitoyl-CoA from acetyl-CoA.

Expert Solution & Answer
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Interpretation Introduction

Interpretation:

Each of the atoms and charges in the equations for the synthesis of palmitoyl CoA and the synthesis of malonyl CoA should be accounted and the overall reaction for the synthesis of palmitoyl CoA from Acetyl CoA should be discussed.

Concept Introduction:

The steps in the synthesis of palmitoyl CoA and the synthesis of malonyl CoA are as follows:

  7 Acetyl-CoA + 7 HCO3 + 7 ATP4 7 malonyl-CoA + 7 ADP3 + 7 Pi2 + 7 H+

  Acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+  palmitoyl-CoA + 7 HCO3 + 14 NADP+ + 7 CoASH

The overall reaction for the synthesis of palmitoyl CoA from acetyl CoA is,

  8 Acetyl-CoA + 7 ATP4 + 14 NADPH + 7 H+                                      palmitoyl-CoA + 14 NADP+ + 7 CoASH + 7 ADP3 + 7 Pi2

Explanation of Solution

In the synthesis of malonyl CoA, the carbons in acetyl group of acetyl CoA is derived from glucose in glycolysis or side chains of amino acids. HCO3- is produced by reacting CO2 and H2O which is catalyzed by carbonic anhydrase. ADP and Pi are the products of ATP hydrolysis. A carbon from bicarbonate ion is incorporated into malonyl CoA while removing a water molecule.

In the synthesis of palmitoyl CoA, acetyl CoA and malonyl CoA is reacted each other and as a result CO2 is released. This CO2 is hydrated and subsequently ionized forming HCO3- ion. Therefore production of protons also occurs. This is why there is an amount protons with half of the amount of NADPH required present on left side of the equation. C-15 and C-16 of palmitoyl CoA are derived from acetyl CoA directly. Remaining carbons are derived indirectly from acetyl CoA via malonyl CoA.

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