Interpretation:
The proper reactant and the proper coupling reaction pathway have to be suggested for the given
Concept Introduction:
Cross coupling:
A cross coupling reaction is defined as a reaction that creates a
In the case of palladium catalysed cross-coupling reactions the other metal or metalloids are commonly
Sonogashira coupling:
The
Generalized reaction,
Suzuki coupling:
The Suzuki coupling uses a boron compound and an alkenyl, aryl or alkyl halide or triflate as the carbon sources with a palladium salt as a catalyst. The reaction is mainly used to form biaryls. The mechanism of the reaction starts with an oxidative addition followed by transmetallation in which the substituent on the borane replaces the ligand on the palladium concluding with the reductive elimination of the palladium to form the new carbon-carbon bond. The base may serve as a new labile ligand to palladium or it may activate the borane by coordination.
Generalized reaction,
Oxidative addition and ligand exchange,
Borane activation
Reaction,
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Organic Chemistry
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- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning