a) Preparation of aniline from benzene Interpretation: How to prepare aniline starting from benzene is to be shown. Concept introduction: The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Question

Following is an outline of a synthesis of the bronchodilator carbuterol, a beta-2 adrenergic blocker with high selectivity for airway smooth muscle receptors. Q. Propose reagents to bring about each step.

Answer 1

Question

Chapter 24.SE, Problem 55AP

Interpretation Introduction

a) Preparation of aniline from benzene

Interpretation:

How to prepare aniline starting from benzene is to be shown.

Concept introduction:

The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Interpretation Introduction

b) Preparation of aniline from benzamide

Interpretation:

How to prepare aniline starting from benzamide is to be shown.

Concept introduction:

In Hofmann degradation reaction amides when treated with Br₂/NaOH are converted into amines which have one carbon less than the amide.

Interpretation Introduction

c) Preparation of aniline from toluene

Interpretation:

How to prepare aniline starting from toluene is to be shown.

Concept introduction:

The steps involved in preparing aniline from toluene are i)Oxidation of methyl group ii) Conversion to acid chloride iii) Conversion in to an amide iv) Hofmann degradation of the amide.

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Following is an outline of a synthesis of the bronchodilator carbuterol, a beta-2 adrenergic blocker with high selectivity for airway smooth muscle receptors. Q. Propose reagents to bring about each step.

Reaction of p-nitroaniline with sodium nitrite and hydrochloric acid at 0°C, followed by treatment with N,N-diethylaniline.

Reaction of p-nitroaniline with sodium nitrite and hydrochloric acid at 0 °C, followed by treatment with N,N-diethylaniline.

Answer 2

Question

Chapter 24.SE, Problem 55AP

Interpretation Introduction

a) Preparation of aniline from benzene

Interpretation:

How to prepare aniline starting from benzene is to be shown.

Concept introduction:

The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Interpretation Introduction

b) Preparation of aniline from benzamide

Interpretation:

How to prepare aniline starting from benzamide is to be shown.

Concept introduction:

In Hofmann degradation reaction amides when treated with Br₂/NaOH are converted into amines which have one carbon less than the amide.

Interpretation Introduction

c) Preparation of aniline from toluene

Interpretation:

How to prepare aniline starting from toluene is to be shown.

Concept introduction:

The steps involved in preparing aniline from toluene are i)Oxidation of methyl group ii) Conversion to acid chloride iii) Conversion in to an amide iv) Hofmann degradation of the amide.

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Answer 3

Question

Chapter 24.SE, Problem 55AP

Interpretation Introduction

a) Preparation of aniline from benzene

Interpretation:

How to prepare aniline starting from benzene is to be shown.

Concept introduction:

The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Interpretation Introduction

b) Preparation of aniline from benzamide

Interpretation:

How to prepare aniline starting from benzamide is to be shown.

Concept introduction:

In Hofmann degradation reaction amides when treated with Br₂/NaOH are converted into amines which have one carbon less than the amide.

Interpretation Introduction

c) Preparation of aniline from toluene

Interpretation:

How to prepare aniline starting from toluene is to be shown.

Concept introduction:

The steps involved in preparing aniline from toluene are i)Oxidation of methyl group ii) Conversion to acid chloride iii) Conversion in to an amide iv) Hofmann degradation of the amide.

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Answer 4

Question

Chapter 24.SE, Problem 55AP

Interpretation Introduction

a) Preparation of aniline from benzene

Interpretation:

How to prepare aniline starting from benzene is to be shown.

Concept introduction:

The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Interpretation Introduction

b) Preparation of aniline from benzamide

Interpretation:

How to prepare aniline starting from benzamide is to be shown.

Concept introduction:

In Hofmann degradation reaction amides when treated with Br₂/NaOH are converted into amines which have one carbon less than the amide.

Interpretation Introduction

c) Preparation of aniline from toluene

Interpretation:

How to prepare aniline starting from toluene is to be shown.

Concept introduction:

The steps involved in preparing aniline from toluene are i)Oxidation of methyl group ii) Conversion to acid chloride iii) Conversion in to an amide iv) Hofmann degradation of the amide.

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Answer 5

Chapter 24.SE, Problem 55AP

Interpretation Introduction

a) Preparation of aniline from benzene

Interpretation:

How to prepare aniline starting from benzene is to be shown.

Concept introduction:

The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Interpretation Introduction

b) Preparation of aniline from benzamide

Interpretation:

How to prepare aniline starting from benzamide is to be shown.

Concept introduction:

In Hofmann degradation reaction amides when treated with Br₂/NaOH are converted into amines which have one carbon less than the amide.

Interpretation Introduction

c) Preparation of aniline from toluene

Interpretation:

How to prepare aniline starting from toluene is to be shown.

Concept introduction:

The steps involved in preparing aniline from toluene are i)Oxidation of methyl group ii) Conversion to acid chloride iii) Conversion in to an amide iv) Hofmann degradation of the amide.

Answer 6

Chapter 24.SE, Problem 55AP

Interpretation Introduction

a) Preparation of aniline from benzene

Interpretation:

How to prepare aniline starting from benzene is to be shown.

Concept introduction:

The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Answer 7

Chapter 24.SE, Problem 55AP

Interpretation Introduction

a) Preparation of aniline from benzene

Interpretation:

How to prepare aniline starting from benzene is to be shown.

Concept introduction:

The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Answer 8

Interpretation Introduction

b) Preparation of aniline from benzamide

Interpretation:

How to prepare aniline starting from benzamide is to be shown.

Concept introduction:

In Hofmann degradation reaction amides when treated with Br₂/NaOH are converted into amines which have one carbon less than the amide.

Answer 9

Interpretation Introduction

b) Preparation of aniline from benzamide

Interpretation:

How to prepare aniline starting from benzamide is to be shown.

Concept introduction:

In Hofmann degradation reaction amides when treated with Br₂/NaOH are converted into amines which have one carbon less than the amide.

Answer 10

Interpretation Introduction

c) Preparation of aniline from toluene

Interpretation:

How to prepare aniline starting from toluene is to be shown.

Concept introduction:

The steps involved in preparing aniline from toluene are i)Oxidation of methyl group ii) Conversion to acid chloride iii) Conversion in to an amide iv) Hofmann degradation of the amide.

Answer 11

Interpretation Introduction

c) Preparation of aniline from toluene

Interpretation:

How to prepare aniline starting from toluene is to be shown.

Concept introduction:

The steps involved in preparing aniline from toluene are i)Oxidation of methyl group ii) Conversion to acid chloride iii) Conversion in to an amide iv) Hofmann degradation of the amide.

Answer 12

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Answer 23

Ch. 24.1 - Name the following compounds:Ch. 24.1 - Prob. 2P Ch. 24.1 - Prob. 3P Ch. 24.3 - Prob. 4P Ch. 24.3 - The benzylammonium ion (C6H5CH2NH3+) has pKa =...Ch. 24.4 - Prob. 6P Ch. 24.5 - Prob. 7P Ch. 24.6 - Prob. 8P Ch. 24.6 - Prob. 9P Ch. 24.6 - Show two methods for the synthesis of dopamine, a...

a) Preparation of aniline from benzene Interpretation: How to prepare aniline starting from benzene is to be shown. Concept introduction: The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Solution Summary: The author explains how to prepare aniline from benzene.

a) Preparation of aniline from benzene

Interpretation:

How to prepare aniline starting from benzene is to be shown.

Concept introduction:

The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

b) Preparation of aniline from benzamide

Interpretation:

How to prepare aniline starting from benzamide is to be shown.

Concept introduction:

In Hofmann degradation reaction amides when treated with Br₂/NaOH are converted into amines which have one carbon less than the amide.

Chapter 24 Solutions

a) Preparation of aniline from benzene Interpretation: How to prepare aniline starting from benzene is to be shown. Concept introduction: The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

Solution Summary: The author explains how to prepare aniline from benzene.

a) Preparation of aniline from benzene Interpretation: How to prepare aniline starting from benzene is to be shown. Concept introduction: The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

b) Preparation of aniline from benzamide Interpretation: How to prepare aniline starting from benzamide is to be shown. Concept introduction: In Hofmann degradation reaction amides when treated with Br2/NaOH are converted into amines which have one carbon less than the amide.

Chapter 24 Solutions

a) Preparation of aniline from benzene

Interpretation:

How to prepare aniline starting from benzene is to be shown.

Concept introduction:

The steps involved in preparing aniline from benzene are i) Nitration of benzene ii) reduction of nitrobenzene.

b) Preparation of aniline from benzamide

Interpretation:

How to prepare aniline starting from benzamide is to be shown.

Concept introduction:

In Hofmann degradation reaction amides when treated with Br₂/NaOH are converted into amines which have one carbon less than the amide.