Biology: The Unity and Diversity of Life (MindTap Course List)
Biology: The Unity and Diversity of Life (MindTap Course List)
15th Edition
ISBN: 9781337408332
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 26, Problem 3CT
Summary Introduction

To explain: The reduced fitness in hybrids arising from genetic incompatibility could have, overtime, led to the elimination of the Neanderthal Y alleles from the H. sapien gene pool.

Concept introduction: Neanderthals and human beings share a common ancestor and both have said to have been occupied closer niches. During these periods, interspecific breeding might have occurred. As a result, current day European and Asian population have Neanderthal DNA in their autosomes. Neanderthals became extinct, but human beings survived.

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In a study of a muscle disorder, several affected families exhibited vision problems, muscle weakness, and deafness (M. Zeviani et al. 1990. American Journal of Human Genetics 47:904–914). Analysis of the mtDNA from affected members of these families revealed that large numbers of their mtDNA molecules possessed deletions of varying lengths. Different members of the same family and even different mitochondria from the same person possessed deletions of different sizes, so the underlying defect appeared to be a tendency for the mtDNA of affected persons to have deletions. A pedigree of one of the families studied is shown below. The researchers concluded that this disorder is inherited as an autosomal dominant trait, and they mapped the diseasecausing gene to a position on chromosome 10 in the nucleus. Q. What characteristics of the pedigree rule out inheritance of a trait encoded by a gene in the mtDNA as the cause of this disorder?
In a study of a muscle disorder, several affected families exhibited vision problems, muscle weakness, and deafness (M. Zeviani et al. 1990. American Journal of Human Genetics 47:904–914). Analysis of the mtDNA from affected members of these families revealed that large numbers of their mtDNA molecules possessed deletions of varying lengths. Different members of the same family and even different mitochondria from the same person possessed deletions of different sizes, so the underlying defect appeared to be a tendency for the mtDNA of affected persons to have deletions. A pedigree of one of the families studied is shown below. The researchers concluded that this disorder is inherited as an autosomal dominant trait, and they mapped the diseasecausing gene to a position on chromosome 10 in the nucleus. Q. Explain how a mutation in a nuclear gene might lead to deletions in mtDNA.
Which of the following findings supports the fact that the presence of the Y-chromosome rather than the lack of a second X-chromosome determines the development of maleness in mammals? a. A human with an X0 genotype (Turner syndrome) is phenotypically female. b. A human with an XXY genotype (Klinefelter syndrome) is phenotypically male. c. A transgenic mouse with two X-chromosomes and the SRY gene from the Y-chromosome develops male sex organs. d. b and c, but not a   e. a, b, and c
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