In peptide analysis, -SH groups of cysteine are capped by S N 2 reaction with iodoacetate. Concept introduction: In preparation for analysis, the peptide is broken into its constituent amino acids by reducing all disulfide bonds, capping the -SH groups of cysteine residues by S N 2 reaction with iodoacetic acid, and hydrolyzing the amide bonds by heating with aqueous 6 M HCl at 110°C for 24 hours. To determine: Structure of product that would be obtained by S N 2 reaction of cysteine and iodoacetic acid.

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Answer 1

Question

Chapter 26.5, Problem 10P

Interpretation Introduction

Interpretation:

In peptide analysis, -SH groups of cysteine are capped by S_N2 reaction with iodoacetate.

Concept introduction:

In preparation for analysis, the peptide is broken into its constituent amino acids by reducing all disulfide bonds, capping the -SH groups of cysteine residues by S_N2 reaction with iodoacetic acid, and hydrolyzing the amide bonds by heating with aqueous 6 M HCl at 110°C for 24 hours.

To determine:

Structure of product that would be obtained by S_N2 reaction of cysteine and iodoacetic acid.

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Answer 2

Question

Chapter 26.5, Problem 10P

Interpretation Introduction

Interpretation:

In peptide analysis, -SH groups of cysteine are capped by S_N2 reaction with iodoacetate.

Concept introduction:

In preparation for analysis, the peptide is broken into its constituent amino acids by reducing all disulfide bonds, capping the -SH groups of cysteine residues by S_N2 reaction with iodoacetic acid, and hydrolyzing the amide bonds by heating with aqueous 6 M HCl at 110°C for 24 hours.

To determine:

Structure of product that would be obtained by S_N2 reaction of cysteine and iodoacetic acid.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 26.5, Problem 10P

Interpretation Introduction

Interpretation:

In peptide analysis, -SH groups of cysteine are capped by S_N2 reaction with iodoacetate.

Concept introduction:

In preparation for analysis, the peptide is broken into its constituent amino acids by reducing all disulfide bonds, capping the -SH groups of cysteine residues by S_N2 reaction with iodoacetic acid, and hydrolyzing the amide bonds by heating with aqueous 6 M HCl at 110°C for 24 hours.

To determine:

Structure of product that would be obtained by S_N2 reaction of cysteine and iodoacetic acid.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 26.5, Problem 10P

Interpretation Introduction

Interpretation:

In peptide analysis, -SH groups of cysteine are capped by S_N2 reaction with iodoacetate.

Concept introduction:

In preparation for analysis, the peptide is broken into its constituent amino acids by reducing all disulfide bonds, capping the -SH groups of cysteine residues by S_N2 reaction with iodoacetic acid, and hydrolyzing the amide bonds by heating with aqueous 6 M HCl at 110°C for 24 hours.

To determine:

Structure of product that would be obtained by S_N2 reaction of cysteine and iodoacetic acid.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 5

Chapter 26.5, Problem 10P

Interpretation Introduction

Interpretation:

In peptide analysis, -SH groups of cysteine are capped by S_N2 reaction with iodoacetate.

Concept introduction:

In preparation for analysis, the peptide is broken into its constituent amino acids by reducing all disulfide bonds, capping the -SH groups of cysteine residues by S_N2 reaction with iodoacetic acid, and hydrolyzing the amide bonds by heating with aqueous 6 M HCl at 110°C for 24 hours.

To determine:

Structure of product that would be obtained by S_N2 reaction of cysteine and iodoacetic acid.

Answer 6

Chapter 26.5, Problem 10P

Interpretation Introduction

Interpretation:

In peptide analysis, -SH groups of cysteine are capped by S_N2 reaction with iodoacetate.

Concept introduction:

In preparation for analysis, the peptide is broken into its constituent amino acids by reducing all disulfide bonds, capping the -SH groups of cysteine residues by S_N2 reaction with iodoacetic acid, and hydrolyzing the amide bonds by heating with aqueous 6 M HCl at 110°C for 24 hours.

To determine:

Structure of product that would be obtained by S_N2 reaction of cysteine and iodoacetic acid.

Answer 7

Chapter 26.5, Problem 10P

Interpretation Introduction

Interpretation:

In peptide analysis, -SH groups of cysteine are capped by S_N2 reaction with iodoacetate.

Concept introduction:

In preparation for analysis, the peptide is broken into its constituent amino acids by reducing all disulfide bonds, capping the -SH groups of cysteine residues by S_N2 reaction with iodoacetic acid, and hydrolyzing the amide bonds by heating with aqueous 6 M HCl at 110°C for 24 hours.

To determine:

Structure of product that would be obtained by S_N2 reaction of cysteine and iodoacetic acid.

Answer 8

Expert Solution & Answer

Answer 9

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Answer 10

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Answer 11

Ch. 26.1 - How many of the -amino acids shown in Table 26-1...Ch. 26.1 - Prob. 2P Ch. 26.1 - Prob. 3P Ch. 26.2 - Hemoglobin has pI=6.8. Does hemoglobin have a net...Ch. 26.3 - Show how you could prepare the following -amino...Ch. 26.3 - What alkyl halides would you use to prepare the...Ch. 26.3 - Prob. 7P Ch. 26.4 - There are six isomeric tripeptides that contain...Ch. 26.4 - Draw the structure of M-P-V-G, and indicate its...Ch. 26.5 - Prob. 10P

Solution Summary: The author explains how the -SH groups of cysteine are capped by S N 2 reaction with iodoacetate.

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