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Crossing Pea Plants: Mendel’s Study of Single Traits Sickle cell anemia (SCA) is a human genetic disorder caused by a recessive allele. A couple plan to marry and want to know the probability that they will have an affected child. With your knowledge of Mendelian inheritance, what can you tell them if (1) each has one affected parent and a parent with no family history of SCA or (2) the man is affected by the disorder but the woman has no family history of SCA?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 3, Problem 9QP
Textbook Problem
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Crossing Pea Plants: Mendel’s Study of Single Traits

Sickle cell anemia (SCA) is a human genetic disorder caused by a recessive allele. A couple plan to marry and want to know the probability that they will have an affected child. With your knowledge of Mendelian inheritance, what can you tell them if (1) each has one affected parent and a parent with no family history of SCA or (2) the man is affected by the disorder but the woman has no family history of SCA?

1.

Summary Introduction

To determine: The probability of a child inheriting sickle cell anemia (SCA) when the parents of the children have one affected member and one with no family history of SCA.

Introduction: Sickle cell anemia is a recessive disorder where the red blood cells get distorted and are produced in a prominent sickle shape. These cells are unable to carry enough oxygen in hemoglobin causing the death of the individual under a low partial pressure of oxygen.

Explanation of Solution

The gametes for the individual affected with SCA are represented as HbS while the gametes of the unaffected individual are represented as HbA. The offsprings produced when one of the parents of the individual is affected and other has no history of sickle cell anemia are as follows:

GametesHbSHbS
HbA

HbAHbS

(carrier)

HbAHbS

(carrier)

HbA

HbAHbS

 (carrier)

HbAHbS

 (carrier)

Thus, all the offsprings will be the carriers of the disease...

2.

Summary Introduction

To determine: The probability that the child will inherit SCA if the father is affected while the mother has no family history of the disease.

Introduction:

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Chapter 3 Solutions

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