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Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
ISBN: 9781337408332

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BuyFindarrow_forward

Biology: The Unity and Diversity o...

15th Edition
Cecie Starr + 3 others
ISBN: 9781337408332
Textbook Problem
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IPSCs are nearly identical to human embryonic stem cells in terms of gene expression, but there may be other ways in which they are not equivalent. For example, the telomeres of IPSCs often vary in length, with many IPSCs cells having telomeres shorter than those of embryonic. How might shortened telomeres affect the life-span of IPSCs or of differentiated cells derived from them?

Summary Introduction

To explain: The way in which the shortened telomeres affect the life-span of IPSCs and differentiated cells derived from them.

Concept introduction: The undifferentiated mass of cells that can differentiate into specific cell types is called as stem cells. There are mainly two types of stem cells – Embryonic stem cells and adult stem cells.

These stem cells are found in multicellular organisms and can be cultured in laboratory. Embryonic stem cells can differentiate into nearly all types of cells found in an organism, whereas adult stem cells can only differentiate into specific cell types. ESCs are pluripotent in nature that is they can differentiate into any cell type such as into muscle cells, nerve cells, blood cells, fat cells, and so on.

Explanation

The pluripotent stem cells have the ability to generate any cell types derived from the three germ layers. The two types of pluripotent stem cells are embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSCs).

Both of them share certain common features such as colony morphology, gene expression, and alkaline phosphatase activity. These cells can differ by the length of telomeres that is IPSCs have shorter telomeres than the ESCs...

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